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Double-stranded oligonucleotide that can suppress the replication of hepatitis C virus protein synthesis or hepatitis C virus /
Double-stranded oligonucleotide that can suppress the replication of hepatitis C virus protein synthesis or hepatitis C virus /
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机译：可抑制丙型肝炎病毒蛋白合成或丙型肝炎病毒复制的双链寡核苷酸/
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摘要
PROBLEM TO BE SOLVED: To suppress the replication of HCV by using siRNA.;SOLUTION: The double-stranded oligonucleotide is composed of an oligonucleotide expressed by formula (I): 5'-S-O1-3' (S is an uninterrupted RNA sequence having a base number of 10-50 and containing the 82nd, 189th, 286th or 331st site in a specific base sequence; O1 is a DNA sequence having a base number of 1-10; 5' means the 5' terminal; and 3' means the 3' terminal) and an oligonucleotide expressed by formula (II): 3'-O2-A-5' (A is an RNA sequence having a base number of 10-30 and complementary to the S; O2 is a DNA sequence having a base number of 1-10; 5' means the 5' terminal; and 3' means the 3' terminal).;COPYRIGHT: (C)2005,JPO&NCIPI
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机译：解决的问题：通过使用siRNA抑制HCV复制。解决方案：双链寡核苷酸由式（I）表示的寡核苷酸组成：5'-SO 1 -3' （S是碱基数为10至50且在特定碱基序列中包含第82、189、286或331st位点的不间断RNA序列; O 1 是碱基数为1-10; 5'表示5'末端; 3'表示3'末端）和由式（II）表示的寡核苷酸：3'-O 2 -A-5'（A是碱基编号为10-30且与S互补的RNA序列; O 2 是碱基编号为1-10的DNA序列; 5'表示5'末端; 3 '表示3'终端）。;版权：（C）2005，JPO＆NCIPI
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