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New bis-platinum complexes with polyamine ligands as antitumor agents
New bis-platinum complexes with polyamine ligands as antitumor agents
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机译:多胺配体作为抗肿瘤剂的新型双铂配合物
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PCT No. PCT/US97/12553 Sec. 371 Date Feb. 16, 1999 Sec. 102(e) Date Feb. 16, 1999 PCT Filed Jul. 22, 1997 PCT Pub. No. WO98/03519 PCT Pub. Date Jan. 29, 1999Bis-platinum(II) complexes with polyamine ligands, including spermidine and spermine, are disclosed. The method of making the bis-platinum(II) complexes, using a DMF complex, and the use of the bis-platinum complexes for the treatment of tumors in mammals are also disclosed. The method of making the polyamine ligands and the use of a new polyamine compound as an intermediate in the synthesis of polyamine ligands are also disclosed.
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