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A composition for the prevention or treatment of acute graft-versus-host disease comprising, as an active ingredient, prodigiosin isolated by Serratia marcescens B-1231KCTC0386BP
A composition for the prevention or treatment of acute graft-versus-host disease comprising, as an active ingredient, prodigiosin isolated by Serratia marcescens B-1231KCTC0386BP
This invention relates to a composition for the prevention and treatment of acute graft-versus-host disease comprising prodigiosin isolated from Serratia marcescence B-1231 KCTC 0386BP, as an effective ingredient. The prodigiosin is immunosup-pressive by selectively suppressing the proliferation of T-cells through the suppression of the expression of IL-2 receptors, which is needed for the activation of T-cells. Prodigiosin can be used either alone or in conjunction with cyclosporin A for greater effect, since the two substances have different mode of actions. These make prodigiosin effective for the prevention and treatment of acute graft-versus-host disease.
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