Contacting quantification method of denatured lipoprotein in a biological sample, which is characterized by quantifying the immune complexes are contacted with an antibody against phosphocholine and the biological sample, resulting, with an antibody against phosphocholine and the biological sample, the present invention results providing a cardiovascular disease detection reagent containing antibodies against phosphocholine and reagent for the determination of denatured lipoprotein, which comprises method for the detection of cardiovascular disease, which is characterized by quantifying the immune complexes, antibodies against phosphocholine.
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