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首页> 外国专利> Methods of treating ovarian and renal cancer using antibodies to immunoglobulin domains of murine domain and mucin domain 1 (TIM-1) antigen

Methods of treating ovarian and renal cancer using antibodies to immunoglobulin domains of murine domain and mucin domain 1 (TIM-1) antigen

机译：使用针对鼠结构域和粘蛋白结构域1（TIM-1）抗原的免疫球蛋白结构域的抗体治疗卵巢癌和肾癌的方法

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摘要

The invention described herein is related to antibodies directed to the antigen TIM-1 and uses of such antibodies for the treatment of cancer (e.g., renal and ovarian cancer). In particular, there are provided fully human monoclonal antibodies directed to the antigen TIM-1. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), specifically from FR1 though FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
机译：本文所述的发明涉及针对抗原TIM-1的抗体，以及此类抗体在治疗癌症（例如，肾癌和卵巢癌）中的用途。特别地，提供了针对抗原TIM-1的完全人单克隆抗体。编码重链和轻链免疫球蛋白分子的分离的多核苷酸序列，以及包含其的氨基酸序列，特别是对应于跨越构架区（FR's）和/或互补决定区（CDR's）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3。还提供了表达此类免疫球蛋白分子和单克隆抗体的杂交瘤或其他细胞系。

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