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Method for the synthesis of aminocrotonylamino substituted quinazoline derivatives

机译:氨基巴豆酰氨基取代的喹唑啉衍生物的合成方法

摘要

The invention relates to an improved process for preparing aminocrotonylamino-substituted quinazoline derivatives of general formula (I) wherein the groups Ra, Rb, Rc and Rd have the meanings given in the claims, as well as sulphonyl derivatives of formula (XIII) and the use thereof as synthesis components for preparing quinazolines of formula (I). The quinazoline derivatives of formula (I) are inhibitors of signal transduction mediated by tyrosinekinases and by the Epidermal Growth Factor-Receptor (EGF-R) and are therefore particularly suitable for the treatment of tumoral diseases.
机译:本发明涉及一种制备通式(I)的氨基巴豆酰氨基取代的喹唑啉衍生物的改进方法,其中基团Ra,Rb,Rc和Rd具有权利要求中的含义,以及式(XIII)的磺酰基衍生物和用作制备式(I)喹唑啉的合成组分的用途。式(I)的喹唑啉衍生物是酪氨酸激酶和表皮生长因子受体(EGF-R)介导的信号转导的抑制剂,因此特别适合于治疗肿瘤疾病。

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