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Method for the synthesis of aminocrotonylamino substituted quinazoline derivatives
Method for the synthesis of aminocrotonylamino substituted quinazoline derivatives
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机译:氨基巴豆酰氨基取代的喹唑啉衍生物的合成方法
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摘要
The invention relates to an improved process for preparing aminocrotonylamino-substituted quinazoline derivatives of general formula (I) wherein the groups Ra, Rb, Rc and Rd have the meanings given in the claims, as well as sulphonyl derivatives of formula (XIII) and the use thereof as synthesis components for preparing quinazolines of formula (I). The quinazoline derivatives of formula (I) are inhibitors of signal transduction mediated by tyrosinekinases and by the Epidermal Growth Factor-Receptor (EGF-R) and are therefore particularly suitable for the treatment of tumoral diseases.
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