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Ligands for influencing the expression of exogenous genes by means of a ecdysone - receptor - complex
Ligands for influencing the expression of exogenous genes by means of a ecdysone - receptor - complex
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机译：通过蜕皮激素-受体-复合物影响外源基因表达的配体
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摘要
This invention relates to an improved method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene. The improvement resides in a select group of non-steroid ligands which show improved activity over known ligands.
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