首页> 外国专利> ROAD CRYSTAL STRUCTURE WITH 5.5.A. RESOLUTION OF THE FUNCTIONAL COMPLEX OF THE BACTERIAL RIBOSOMS, CONTAINING TRANSFERS AND MODEL BOTTERS

ROAD CRYSTAL STRUCTURE WITH 5.5.A. RESOLUTION OF THE FUNCTIONAL COMPLEX OF THE BACTERIAL RIBOSOMS, CONTAINING TRANSFERS AND MODEL BOTTERS

机译：5.5.A.的道路晶体结构包含转移和模型苦味的细菌核糖体功能复数的解析

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摘要

5.5 Angstrom resolution x-ray crystallographic structures of 70S ribosome complexes containing messenger RNA and tranfer RNA (tRNA), or tRNA analogs, are provided. The resolution has been enhanced by fitting atomic resolution structures of 30S and 50S subunits onto the 5.5 anstrong electron density map. The enhanced structure reveals regions of structural differences between the 70S complex and the structures of the individual 30S and 50S components. Pharmacophore design to discover novel inhibitors or activators may be carried out using the enhanced 5.5 Angstrom 70S structure.

机译：提供了含有信使RNA和转移RNA（tRNA）或tRNA类似物的70S核糖体复合物的5.5埃分辨率X射线晶体学结构。通过将30S和50S亚基的原子分辨率结构拟合到5.5 anstrong电子密度图上，可以提高分辨率。增强的结构揭示了70S复合体与单个30S和50S组件的结构之间的结构差异区域。使用增强的5.5埃70S结构可以进行发现新抑制剂或活化剂的药理学设计。

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公开/公告号DE60132815D1

专利类型
公开/公告日2008-03-27

原文格式PDF
申请/专利权人 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;
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申请/专利号DE20016032815T
发明设计人 NOLLER HARRY F.;CATE JAMIE H.D.;YUSUPOV MARAT M.;YUSUPOVA GULNARA ZH.;BAUCOM ALBION E.;LANCASTER LAURA;DALLAS ANNE;LIEBERMANN KATHY;
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申请日2001-12-10
分类号C07K14/195;G01N23/20;G01N33/15;G01N33/48;G01N33/50;G01N33/566;G01N33/68;G06F17/30;
国家 DE
入库时间 2022-08-21 19:48:27

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