首页> 外国专利> Particle from a polymer material, useful e.g. in the medicinal diagnostic kit, comprises monodisperse in the material embedded fluorophore with absorption and fluorescence maxima in the ultraviolet/visible/near infra red-spectral area

Particle from a polymer material, useful e.g. in the medicinal diagnostic kit, comprises monodisperse in the material embedded fluorophore with absorption and fluorescence maxima in the ultraviolet/visible/near infra red-spectral area

机译：来自聚合物材料的颗粒，例如有用的。在医学诊断工具包中，包括单分散在材料中的嵌入的荧光团，在紫外/可见/近红外光谱区域具有吸收和荧光最大值

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Particle from a polymer material, comprises two or more monodisperse in the material embedded fluorophore with absorption- and fluorescence maxima in the ultraviolet/visible/near infra red-spectral area, where the fluorophore is selected in such a manner that the absorption maxima of the fluorophore are at least around 5 nm; the fluorescence maxima of the fluorophore are at least around 10 nm; and the absorption maxima and the fluorescence maxima of the fluorophore are at least around 5 nm. Independent claims are included for: (1) a test-kit containing two or more charges of the particles, where the charges contain the same fluorophore with different concentration ratio; (2) production of the particles comprising polymerizing a solution/molecular or colloidal dispersion of the fluorophore in a monomer/monomer mixture; and (3) identification of the particles in a sample, comprising (i) irradiating particles preferably present in monolayer with one or more excitation wavelength in the overlapping area of the absorption spectra of the fluorophore and/or in the areas of the absorption maxima of the fluorophore (+- 10% of the extinction), (ii) capturing the intensities of the fluorescence at the above mentioned measuring point, where each fluorophore contained in the particle is given with a measuring point, which lies in an area of at least 5% of the intensity of the fluorescence maximum of the respective fluorophores and where the measuring points are spaced around at least 5 nm from one another, (iii) determining an intensity ratios of the intensities captured at the measuring point and comparing the determined intensity ratio with a reference value for the identification of the particles.

机译：来自聚合物材料的颗粒包含两种或多种单分散在材料中的嵌入式荧光团，在紫外/可见/近红外光谱区域具有吸收和荧光最大值，其中选择荧光团的方式应使其最大吸收荧光团至少约5 nm;荧光团的荧光最大值至少约为10nm。荧光团的吸收最大值和荧光最大值至少约为5nm。包括以下独立权利要求：（1）包含两个或多个粒子电荷的测试套件，其中这些粒子包含具有不同浓度比的相同荧光团; （2）制备颗粒，包括使荧光团在单体/单体混合物中的溶液/分子或胶体分散体聚合; （3）鉴定样品中的颗粒，包括（i）优选在荧光团的吸收光谱的重叠区域和/或在最大吸收峰的区域中以优选具有一个或多个激发波长的单层形式存在的辐射颗粒。荧光团（消光的±10％），（ii）在上述测量点处捕获荧光强度，其中颗粒中包含的每个荧光团都带有一个测量点，该测量点至少位于各个荧光团的最大荧光强度的5％，并且测量点之间的距离至少约5 nm，（iii）确定在测量点处捕获的强度的强度比并比较确定的强度比具有用于识别颗粒的参考值。

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公开/公告号DE102007010860A1

专利类型
公开/公告日2008-09-04

原文格式PDF
申请/专利权人 POLY-AN GESELLSCHAFT ZUR HERSTELLUNG VON POLYMEREN FUER SPEZIELLE ANWENDUNGEN UND ANALYTIK MBH;
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申请/专利号DE20071010860
发明设计人 DIMROTH JONAS;SCHEDLER UWE;THIELE THOMAS;REXIN HEIKO;
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申请日2007-03-01
分类号C09B67/22;B01J13/18;A61K49/00;G01N21/64;
国家 DE
入库时间 2022-08-21 19:49:22

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