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METHOD FOR LABELING PHOSPHORYLATED PEPTIDES, METHOD FOR SELECTIVE ADSORPTION OF PHOSPHORYLATED PEPTIDES, CHELATING COMPOUNDS USED IN SUCH METHODS, METHOD FOR PREPARING CHELATING COMPOUNDS AND PARENT COMPOUNDS FOR PREPARING CHELATING COMPOUNDS
METHOD FOR LABELING PHOSPHORYLATED PEPTIDES, METHOD FOR SELECTIVE ADSORPTION OF PHOSPHORYLATED PEPTIDES, CHELATING COMPOUNDS USED IN SUCH METHODS, METHOD FOR PREPARING CHELATING COMPOUNDS AND PARENT COMPOUNDS FOR PREPARING CHELATING COMPOUNDS
FIELD: organic chemistry, peptides.;SUBSTANCE: invention proposes a method for labeling phosphorylated peptides, method for adsorption of phosphorylated peptides and compounds possessing high coordination capacity with respect to phosphorylated peptides that are used in such methods, and compounds used as parent substances. Chelating compound is represented by the formula (I): wherein X represents linker group; Y represents fluorescent group or biotin as labeling group. Compound of the formula (I) provides easy detection and identification of phosphorylated peptide in a sample prepared from a living body.;EFFECT: improved methods of preparing and analysis.;13 cl, 9 dwg, 8 ex
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机译:领域:本发明提出了标记磷酸化肽的方法,吸附磷酸化肽的方法和相对于用于这种方法的磷酸化肽具有高配位能力的化合物,以及用作母体物质的化合物。螯合化合物由式(I)表示:其中X表示连接子组; Y代表荧光基团或生物素作为标记基团。式(I)化合物可轻松检测和鉴定从活体制备的样品中的磷酸化肽;效果:改进的制备和分析方法; 13 cl,9 dwg,8 ex
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