首页> 外国专利> COMBINATORIAL FRAGMID LIBRARY OF HUMAN SINGLE-STRANDED ANTIBODIES ENRICHED WITH ANTIBODIES AGAINST VARIOLOVACCINE VIRUS, RECOMBINANT FRAGMID pHEN-2A8 DNA CONTAINING UNIQUE GENE OF HUMAN SINGLE-STRANDED ANTIBODY, CAPABLE OF NEUTRALIZING VARIOLOVACCINE VIRUS AND COWPOX VIRUS, AND ARTIFICIAL HUMAN SINGLE-STRANDED 2A8 ANTIBODY CAPABLE OF NEUTRALIZING VARIOLOVACCINE VIRUS AND COWPOX VIRUS

COMBINATORIAL FRAGMID LIBRARY OF HUMAN SINGLE-STRANDED ANTIBODIES ENRICHED WITH ANTIBODIES AGAINST VARIOLOVACCINE VIRUS, RECOMBINANT FRAGMID pHEN-2A8 DNA CONTAINING UNIQUE GENE OF HUMAN SINGLE-STRANDED ANTIBODY, CAPABLE OF NEUTRALIZING VARIOLOVACCINE VIRUS AND COWPOX VIRUS, AND ARTIFICIAL HUMAN SINGLE-STRANDED 2A8 ANTIBODY CAPABLE OF NEUTRALIZING VARIOLOVACCINE VIRUS AND COWPOX VIRUS

机译：人类单链抗体复合弗拉芒氏文库，富含抗痘苗病毒的抗体，包含人类单链抗体的独特基因的重组弗拉芒肽phen-2A8 DNA，可融合中性和酸性，可折叠的，呈核糖体和带瘤的，带菌体，带菌体，带菌体，带菌体，带菌体，带菌体，带菌体，带菌体，带菌体，带菌体，带毒，带毒，带毒，带毒，带毒，带毒，带毒，带毒，带毒，带毒，带毒，带毒，带毒。痘病毒和COWPOX病毒的中和分析

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FIELD: biotechnology, protein engineering.;SUBSTANCE: claimed library represents E.coli TGI cells wherein each cell contains fragmid DNA providing biosynthesis of filamentous bacteriophages exposing unique human single-stranded antibody on surface thereof. Also disclosed is recombinant fragmid pHEN-2A8 DNA containing artificial gene of human single-stranded antibody under control of lactose operon promoter providing synthesis of human single-stranded antibody in composition of chimerical protein with membrane pIII protein of M13 bacteriophage in E.coli cells. Also disclosed is method for production of artificial human single-stranded 2A8 antibody by using such fragmid DNA.;EFFECT: fragmid library useful in medicine.;3 cl, 7 dwg, 10 ex

机译：领域：要求保护的文库代表大肠杆菌TGI细胞，其中每个细胞均含有提供生物合成丝状噬菌体的fragmid DNA，该噬菌体在其表面上暴露出独特的人单链抗体。还公开了包含在乳糖操纵子启动子控制下的人单链抗体的人工基因的重组fragmid pHEN-2A8 DNA，其提供了人单链抗体在大肠杆菌细胞中的嵌合蛋白与M13噬菌体的膜pIII蛋白的组合物中的合成。还公开了通过使用这样的fragmid DNA生产人工人单链2A8抗体的方法。效果：在医学上有用的fragmid文库; 3 cl，7 dwg，10 ex

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公开/公告号RU2311927C2

专利类型
公开/公告日2007-12-10

原文格式PDF
申请/专利权人 FEDERALNOE GOSUDARSTVENNOE UNITARNOE UCHREZHDENIE NAUKI GOSUDARSTVENNYJ NAUCHNYJ TSENTR VIRUSOLOGII I BIOTEKHNOLOGII VEKTOR FEDERALNOJ SLUZHBY PO NADZORU V SFERE ZASHCHITY PRAV POTREBITELEJ I BLAGOPOLUCHIJA CHELOVEKA;
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申请/专利号RU20050125994
发明设计人 DUBROVSKAJA VIKTORIJA VLADISLAVOVNA;TIKUNOVA NINA VIKTOROVNA;MOROZOVA VERA VITALEVNA;BORMOTOV NIKOLAJ IVANOVICH;LAMAN ALEKSANDR GEORGIEVICH;ULITIN ANDREJ BORISOVICH;BROVKO FEDOR ALEKSANDROVICH;BELANOV EVGENIJ FEDOROVICH;ILICHEV ALEKSANDR ALEKSEEVICH;
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申请日2005-08-15
分类号A61K39/42;C12N15/39;C07K16/08;
国家 RU
入库时间 2022-08-21 19:50:55

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