首页> 外国专利> Monoclonal antibodies immunoreactive with nucleocapsid protein (CDF) hepatitis C virus-4G5, a method of diagnosing - SANDWICH OPTION immunosorbent quantitative analysis to detect hepatitis C virus nucleocapsid and a combination of monoclonal antibodies include mAb 4G5, FOR IMPLEMENTATION

Monoclonal antibodies immunoreactive with nucleocapsid protein (CDF) hepatitis C virus-4G5, a method of diagnosing - SANDWICH OPTION immunosorbent quantitative analysis to detect hepatitis C virus nucleocapsid and a combination of monoclonal antibodies include mAb 4G5, FOR IMPLEMENTATION

机译:与核衣壳蛋白(CDF)丙型肝炎病毒4G5发生免疫反应的单克隆抗体-一种诊断方法-SANDWICH OPTION免疫吸附定量分析以检测丙型肝炎病毒的核衣壳,单克隆抗体的组合包括mAb 4G5,用于实施

摘要

1. monoclonal antibodies 4G5, u043fu0440u043eu0434u0443u0446u0438u0440u0443u0435u043cu044bu0435 strains cultured cells Mus hybrid mice. Musculus, u0438u043cu043cu0443u043du043eu0440u0435u0430u043au0442u0438u0432u043du044bu0435 protein u043du0443u043au043bu0435u043eu043au0430u043fu0441u0438u0434u0430 (in white) of hepatitis c virus (hcv) and specific to the u043au043eu043du0444u043eu0440u043cu0430u0446u0438u043eu043du043du043e - dependent u0430u043du0442u0438u0433u0435u043du043du043eu0439 u0434u0435u0442u0435u0440u043cu0438u043du0430u043du0442u0435 at station 1 - 150 u0430u043cu0438u043du043eu043au0438u0441u043bu043eu0442u043du044bu0445 residues in the protein of hcv.;2.method of diagnosing hcv infection, including hepatitis c virus core protein u0432u044bu00a0u0432u043bu0435u043du0438u0435 - in a version of quantitative analysis by the use of immune enzyme u043du0438u00a0 combinations of monoclonal antibodies, u0438u043cu043cu0443u043du043eu0440u0435u0430u043au0442u0438u0432u043du044bu0445 with core protein, hepatitis c virus, u043eu0442u043bu0438u0447u0430u044eu0449u0438u0439u0441u00a0, used in conjunction 2 monoclonal antibodies 7.1F9 and 4G5 directed to linear and u043au043eu043du0444u043eu0440u043cu0430u0446u0438u043eu043du043du043e - dependent u044du043fu0438u0442u043eu043fu0430u043c (u0430u043du0442u0438u0433u0435u043du043du044bu043c determinants) in the protein of hcv, ica 1F9 - linear u044du043fu0438u0442u043eu043fu0443 amino acid supplemented diets residues (s.a.) 81 - 85, ica 27 and 4G5 - u043au043eu043du0444u043eu0440u043cu0430u0446u0438u043eu043du043du043e - dependent u044du043fu0438u0442u043eu043fu0430u043c at station 1 - 150 s.a.. in the protein.;3. u043au043eu043cu0431u0438u043du0430u0446u0438u00a0 monoclonal antibody 27, 1F9 and 4G5, u0438u043cu043cu0443u043du043eu0440u0435u0430u043au0442u0438u0432u043du044bu0445 protein u043du0443u043au043bu0435u043eu043au0430u043fu0441u0438u0434u0430 hepatitis c virus and used u0434u043bu00a0 capture (exciting antibodies) and u0434u043bu00a0 d. u0435u0442u0435u043au0446u0438u0438 (u0434u0435u0442u0435u043au0442u0438u0440u0443u044eu0449u0438u0435 antibodies) in the protein on p.2.
机译:1.单克隆抗体4G5, u043f u0440 u043e u0434 u0443 u0446 u0438 u0440 u0443 u0435 u043c u044b u0435株培养了Mus杂种小鼠。肌肉, u0438 u043c u043c u0443 u043d u043e u0440 u0435 u0430 u043a u0442 u0438 u0432 u043d u043d u044b u0435蛋白 u043d u0443 u043a u043a u043b u0435 u043e u043e u043a u0430 u043f u0441 u0438 u0434 u0430(白色),且特定于 u043a u043e u043d u0444 u043e u0440 u043c u0430 u0446 u0438 u043e u043d u043d u043e-依赖 u0430 u043d u0442 u0438 u0433 u0435 u043d u043d u043d u043e u0439 u0434 u0435 u0442 u0435 u0440 u043c u0438 u043d u043d u04330 u043d u0432在站1-hcv蛋白中的150个残基 u0430 u043c u0438 u043d u043e u043a u0438 u0441 u043b u043e u0442 u043d u044b u0445中的残基; 2.诊断hcv感染的方法,包括丙型肝炎病毒核心蛋白 u0432 u044b u00a0 u0432 u043b u0435 u043d u0438 u0435-使用免疫酶 u043d u0438 u00a0单克隆抗体组合, u0438 u043c u043c u0443 u043d u043e u0440 u0435 u0430 u043a u0442 u0438 u0432 u043d u044b u0445具有核心蛋白,肝丙型病毒, u043e u0442 u043b u0438 u0447 u0430 u044e u0449 u0438 u0439 u0441 u00a0,与2个针对线性和 u043a u043e u043d的单克隆抗体7.1F9和4G5结合使用u0444 u043e u0440 u043c u0430 u0446 u0438 u043e u043d u043d u043d u043e-从属 u044d u043f u0438 u0442 u043e u043f u0430 u043c( u0430 u043d u0442 u0438 HCV,ICA 1F9蛋白中的 u0435 u043d u043d u044b u043c决定簇)-补充饮食的氨基酸残基(sa)81-85,ica 27线性 u044d u043f u0438 u0442 u043e u043f u0443和4G5- u043a u043e u043d u0444 u043e u0440 u043c u0430 u0446 u0438 u043e u043d u043d u043d u043e-从属 u044d u043f u0438 u0442 u043e u043f u0430 u043c蛋白质中位于1到150个sa .; 3。 u043a u043e u043c u0431 u0438 u043d u0430 u0446 u0438 u00a0单克隆抗体27、1F9和4G5, u0438 u043c u043c u0443 u043d u043d u043e u0440 u0435 u0430 u043a u043a u2 u0438 u0432 u043d u044b u0445蛋白 u043d u0443 u043a u043b u0435 u0435 u043e u043a u0430 u043f u0441 u0438 u0434 u0430丙型肝炎病毒并使用 u0434 u043b u00a0捕获(令人兴奋的抗体)和 u0434 u043b u00a0 d。第2页上的蛋白质中的 u0435 u0442 u0435 u043a u0446 u0438 u0438( u0434 u0435 u0442 u0435 u043a u0442 u0438 u0440 u0443 u044e u0449 u0449 u0438 u0435抗体) 。

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