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A PHARMACEUTICAL COMPOSITION FOR RENDERING RESISTANCE TO CISPLATIN IN CANCER CELLS COMPRISING A MATERIAL INHIBITING AN EXPRESSION OF CYCLOPHILIN A AND A METHOD FOR RENDERING RESISTANCE TO CISPLATIN IN CANCER CELLS BY USING THEM
A PHARMACEUTICAL COMPOSITION FOR RENDERING RESISTANCE TO CISPLATIN IN CANCER CELLS COMPRISING A MATERIAL INHIBITING AN EXPRESSION OF CYCLOPHILIN A AND A METHOD FOR RENDERING RESISTANCE TO CISPLATIN IN CANCER CELLS BY USING THEM
A pharmaceutical composition comprising a material for inhibiting expression of cyclophilin A is provided to inhibit resistance to cisplatin of cancer cells and reduce cisplatin resistance of solid cancer, so that the composition is useful for increasing therapeutic effects of cisplatin on solid cancer. A pharmaceutical composition for inhibiting resistance to cisplatin of solid cancer of a patient having no p53 gene comprises a material inhibiting expression of cyclophilin A, having PPIase(peptidyl-prolyl-cis-trans isomerase) activity, which is selected from siRNA(small interfering RNA) having the nucleotide sequence of SEQ ID NO:1 and an antisense nucleic acid, wherein the solid cancer is prostate cancer, cervical cancer or colon cancer.
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机译：提供了包含抑制亲环蛋白A表达的材料的药物组合物，以抑制癌细胞对顺铂的抗性并降低实体癌对顺铂的抗性，因此该组合物可用于提高顺铂对实体癌的治疗效果。用于抑制没有p53基因的患者的实体癌对顺铂耐药的药物组合物，其包含具有PPIase（肽基-脯氨酰-顺式-反式异构酶）活性的抑制亲环素A表达的物质，该物质选自siRNA（小干扰RNA） ）具有SEQ ID NO：1的核苷酸序列和反义核酸，其中所述实体癌是前列腺癌，子宫颈癌或结肠癌。
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