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EXPERIMENTAL ANIMAL AS PATHOLOGICAL MODEL, METHOD OF PRODUCING THE EXPERIMENTAL ANIMAL, AND METHOD OF USING THE EXPERIMENTAL ANIMAL

机译:实验动物作为病理模型,生产实验动物的方法以及使用实验动物的方法

摘要

[PROBLEMS] To provide a novel experimental animal as pathological model that is capable of reproduction from fatty liver to progressive human nonalcoholic chronic hepatitis and/or hepatic fibrosis and/or cirrhosis, and provide a method of producing the same and a method of using the novel experimental animal as pathological model. [MEANS FOR SOLVING PROBLEMS] An in vivo low oxygen condition is created in a fatty-liver-carrying model experimental animal, finally producing an experimental animal as pathological model holding the biochemical characteristics and/or histopathological characteristics of nonalcoholic fatty hepatitis and/or cirrhosis.
机译:[问题]提供一种能够从脂肪肝向人类进行性非酒精性慢性肝炎和/或肝纤维化和/或肝硬化繁殖的新型实验动物作为病理模型,并提供其制备方法和使用该动物的方法新型实验动物作为病理模型。 [解决问题的方法]在携带脂肪肝的模型实验动物中创建体内低氧条件,最终产生具有非酒精性脂肪肝和/或肝硬化的生化特征和/或组织病理学特征的病理模型作为实验动物。 。

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