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CRYSTAL STRUCTURE OF A SUBSTRATE COMPLEX OF NAMPT/PBEF/VISFATIN
CRYSTAL STRUCTURE OF A SUBSTRATE COMPLEX OF NAMPT/PBEF/VISFATIN
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机译：NAMPT / PBEF / VISFATIN底物复合物的晶体结构
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摘要
Nicotinamide phosphoribosyltransferase (Nampt) synthesizes nicotinamide mononucleotide (NMN) from nicotinamide in a mammalian NAD+ biosynthetic pathway and is required for SirTl activity in vivo. Nampt has also been presumed to be a cytokine (PBEF) or a hormone (visfatin). The crystal structure of Nampt in the presence and absence of NMN shows that Nampt is a dimeric type II phosphoribosyltransferase and provides insights into the enzymatic mechanism. The structure also reveals the basis of substrate specificity and suggests routes for the development of specific Nampt inhibitors for treatment of Nampt-associated disorders.
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