首页> 外国专利> MODIFIED TRAFFICKING PATTERNS FOR ARRESTIN AND G-PROTEIN-COUPLED RECEPTORS VIA ARRESTIN-UBIQUITIN CHIMERA

MODIFIED TRAFFICKING PATTERNS FOR ARRESTIN AND G-PROTEIN-COUPLED RECEPTORS VIA ARRESTIN-UBIQUITIN CHIMERA

机译:通过ARRESTIN-UBIQUITIN CHIMERA修饰的ARRESTIN和G-蛋白偶联受体的运输模式

摘要

The present invention relates to a modified arrestin which includes an arrestin molecule and a ubiquitin molecule. This modified arrestin has an increased affinity for a GPCR, and traffics with the GPCR into endosomes. The present invention further relates to a method of screening compounds and sample solutions for a GPCR agonist, antagonist, inverse agonist, or desensitization active compound. The modified arrestin is useful in the methods of the present invention.
机译:本发明涉及一种修饰的抑制蛋白,其包括抑制蛋白分子和泛素分子。这种修饰的抑制蛋白对GPCR的亲和力增强,并随GPCR进入内体。本发明进一步涉及一种筛选用于GPCR激动剂,拮抗剂,反向激动剂或脱敏活性化合物的化合物和样品溶液的方法。修饰的抑制蛋白可用于本发明的方法。

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