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COMPOUNDS IN THE FORM OF HOMODIMERIC OR HETERODIMERIC PROPHARMACTS, PROCEDURE TO OBTAIN THESE PROFARMACTS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AND USE OF THE COMPOUNDS IN THE TREATMENT OF DISEASES OR DYSFUNCTION MEDIATED BY PHOSPHODIESTERS.
COMPOUNDS IN THE FORM OF HOMODIMERIC OR HETERODIMERIC PROPHARMACTS, PROCEDURE TO OBTAIN THESE PROFARMACTS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AND USE OF THE COMPOUNDS IN THE TREATMENT OF DISEASES OR DYSFUNCTION MEDIATED BY PHOSPHODIESTERS.
Homodimeric or heterodimeric prodrugs in which the monomer units are compounds of 1,6-dihydro-7H-pyrazolo [4,3-d] pyrimidin-7-one of the formula: (See formula) where R1 can be -H, - C1-C6 alkyl, -C1-C6-OH, or -C1-C6-NHR ", where R" may be -H, or -C1-C6 alkyl; R2 can be -H, -C1-C6 alkyl, -C1-C6-OH, or -C1-C6-NR '', where R '' can be -H, or -C1-C6 alkyl; where R3 is: (See formula) where R4 can be -H, C1-C6 alkyl, -C1-C6-OH or C1-C6-NHR '', where R '' can be -H, or C1- alkyl C6-; and R5 can be -H, -OH, -NHR '', -C1-C6 alkyl, -C1-C6-OH or C1-C6-NHR '', where R '' can be -H or C1-C6 alkyl- ; or R5 can be: (See formula) where R6 can be H, morpholine, piperidine, hydroxyalkylpiperazine, aminoalkylpiperazine, where alkyl can be from C1 to C6; in which the monomer units are linked together by bridges that are selected from the group consisting of carbonate (-O-COO-), carbamate (-O-CO-N-), urea (-N-CO-N-) or phosphate (-O-POO-O-), and in which the active drug is generated after excision "in vivo" of the bridges.
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