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Combination therapy to produce weight loss and treat obesity.
Combination therapy to produce weight loss and treat obesity.
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机译:组合疗法可减轻体重并治疗肥胖症。
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摘要
The use of a combination of a sympathomimetic agent and an anticonvulsant sulfamate derivative for the preparation of a medicament for weight loss in a subject, the sympathomimetic agent being phenylethylamine, epinephrine, norepinephrine, epinine, dopamine, dabutamine, nordephrine, ethylnorepinephrine, isoproterenol, Protokylol, isoetharine, metaproterenol, terbutaline, metaraminol, phenylephrine, tyramine, hydroxyamphetamine, methoxyphenamine, methoxamine, albuterol, amphetamine, methamphetamine, benzphetamine, ephedrine, phenylpropanolamine, mephentermine, phentermine, chlorphentermine, fenfluramine, tuaminoheptane, propylhexedrine, diethylpropion, phenmetrazine, or phendimetrazine, and being the anticonvulsant sulfamate derivative of formula I: where X is CH2 or oxygen; R1 is hydrogen or alkyl; and R2, R3, R4 and R5 are independently hydrogen or C1-C4 alkyl; when X is oxygen, R2 and R3 and / or R4 and R5 together can be a methylenedioxy group of the following formula II: where R6 and R7 are the same or different and are hydrogen, C1-C3 alkyl or can be taken together to form a cyclopentyl or cyclohexyl ring.
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