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continuous process for arrangement of makromolekulu00e4ren substances and subsequent absorption and isolation of a makromolekulu00e4ren arrangementand a suitable system for this process
continuous process for arrangement of makromolekulu00e4ren substances and subsequent absorption and isolation of a makromolekulu00e4ren arrangementand a suitable system for this process
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机译：制备大分子化合物的连续过程以及随后的大分子化合物的吸收和分离，以及该方法的合适系统
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摘要
The present invention relates to a continuous process and a system for macromolecular assembly and capture (refolding or proteins (e.g. refolding of HAT human beta2-microglobulin), hybridization of nucleic acid, nucleic acid analogues, and protein-nucleic acid chimera, aggregation of carbohydrates, and assembly of nanostructures/nanomaterials. The process may comprise the steps of providing fluid compositions comprising at least one of said macromolecular substances in a predominantly unassembled form, providing a dispersion comprising coated, essentially non-porous magnetic particles, combining said fluid compositions and the dispersion of magnetic particles thereby providing a continuous stream, passing said continuous stream through a first mixing device thereby forming magnetic complexes each comprising a magnetic particle and a plurality of macromolecular assembly species; passing the continuous stream through a first capture compartment of a magnetic separator thereby capturing said magnetic complexes; and separating said magnetic complexes from said continuous stream, and isolating said macromolecular assembly species.
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