首页> 外国专利> Compound 8 - azabiciclo 3.2.1 oct 8 - il - 1,2,3,4 - Tetrahidroquinolina replaced as inhibitors HSD1 11B

Compound 8 - azabiciclo 3.2.1 oct 8 - il - 1,2,3,4 - Tetrahidroquinolina replaced as inhibitors HSD1 11B

机译：化合物8-杜鹃花[3.2.1]十月8-il-1,2,3,4-四羟基喹啉取代作抑制剂HSD11B

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Refers to a compound of formula I, where X is c, o, S, N, SO2; The dotted link is a Link simple double; A1A, r1b, r1c, R1D, 2A and R2B are each h, halogen, alkyl (C1 - C5), among others; R3 is H, alkyl (C1 - C5), alkoxy (C1 - C5), among others; R4 is H, alkyl, cycloalkyl - C1 - C6 C3, C5, Among others, P and R are 1 - 2.Preferred compounds are: hydrochloride 1 - [(3 - pyridin-3-yl - 8 - azabiciclo [3.2.1] oct 8 - il) carbonyl] - 1,2,3,4 - Tetrahidroquinolina hydrochloride; {[1 - (3 - endo) - 3 - (pyridin-2-yl - Oct 8 - azabiciclo [3.2.1] - il - 8] carbonyl} - 1,2,3,4 - tetrahidroquinolina; among others. Also referred to a Pharmaceutical Composition and a preparation method.Described are compounds of the Enzyme 11beta-hsd1 inhibitors useful in the treatment of Obesity, diabetes, insulin resistance, Metabolic Disorder, hypertension, among others

机译：指式I化合物，其中X为c，o，S，N，SO 2;虚线链接是一个链接简单的双; A 1A，r 1b，r 1c，R 1D，2A和R 2B分别是h，卤素，烷基（C1-C5）等。 R3为H，烷基（C1-C5），烷氧基（C1-C5）等。 R 4是H，烷基，环烷基-C 1 -C 6 C 3，C 5，其中，P和R是1-2。优选的化合物是：盐酸盐1-[（3-吡啶3--3-基-8-杜鹃花[3.2.1]。 ] oct 8-il）羰基]-1,2,3,4-盐酸四氢喹啉; {[1-（3-内）-3-（吡啶-2-基-Oct 8-杜鹃花[3.2.1]-il-8]羰基}-1,2,3,4-四氢喹啉;除其他外。涉及药物组合物和制备方法。描述了用于治疗肥胖症，糖尿病，胰岛素抵抗，代谢紊乱，高血压等的酶11beta-hsd1抑制剂的化合物

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公开/公告号PE03442008A1

专利类型
公开/公告日2008-06-09

原文格式PDF
申请/专利权人 SANOFI-AVENTIS;
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申请/专利号PE20070000811
发明设计人 MOUGENOT PATRICK;GUSSREGEN STEFAN;ALETRU MICHEL;NICOLAI ERIC;BRAUN ALAIN;NAMANE CLAUDIE;VENIER OLIVIER;PHILIPPO CHRISTOPHE;
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申请日2007-06-25
分类号A61K31/46;A61P3/04;A61P3/10;A61P9/10;A61P19/10;A61P25/28;C07D471/08;
国家 PE
入库时间 2022-08-21 20:06:34

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