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Use of polymorphisms in human OATP-C associated with an effect on statin pharmacokinetics in humans during statin therapy
Use of polymorphisms in human OATP-C associated with an effect on statin pharmacokinetics in humans during statin therapy
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机译:在人类OATP-C中使用多态性与他汀类药物治疗期间对人类他汀类药物代谢动力学的影响有关
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摘要
This invention relates to use of polymorphisms in human OATP-C in statin therapy because they are associated with an effect on statin pharmacokinetics (PK) in humans, especially rosuvastatin pharmacokinetics. The invention also relates to the use of OATP-C polymorphisms in predicting the efficacy and safety of statins, whose uptake in to the liver is mediated by OATP-C, especially rosuvastatin.
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