首页> 外国专利> Method for producing human monoclonal antibody, method for the production of human b Lymphocyte Composition of Human Antibody producing B lymphocytes; Immortal; use of an animal for PRoducir Immortal B lymphocytes; method to produ

Method for producing human monoclonal antibody, method for the production of human b Lymphocyte Composition of Human Antibody producing B lymphocytes; Immortal; use of an animal for PRoducir Immortal B lymphocytes; method to produ

机译：人单克隆抗体的生产方法，人b淋巴细胞的生产方法，人抗体生产b淋巴细胞的组成。不朽;动物用于生产PRoducir永生B淋巴细胞;生产方法

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摘要

The current invention is related to a method for the production of a human monoclonal antibody from a immunodeficient non-human animal, said method comprising contacting a new borne immunodeficient non-human animal with a human fetal liver stem cell (FL cell) to generate an immune transplanted non-human animal (reconstituted animal), subsequently contacting said reconstituted animal with a antigen, collecting from said reconstituted animal a human cell producing human antibody against said antigen, and isolating said antibody from said antibody producing cell.

机译：本发明涉及一种由免疫缺陷的非人类动物生产人单克隆抗体的方法，所述方法包括使新传播的免疫缺陷的非人类动物与人胎儿肝干细胞（FL细胞）接触以产生人单克隆抗体。免疫移植的非人类动物（重组动物），随后使所述重组动物与抗原接触，从所述重组动物中收集产生针对所述抗原的人抗体的人细胞，并从所述产生抗体的细胞中分离所述抗体。

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公开/公告号CL2007001346A1

专利类型
公开/公告日2008-03-14

原文格式PDF
申请/专利权人 F. HOFFMANN-LA ROCHE AG.;
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申请/专利号CL20070001346
发明设计人 ALEXANDER LIFKE;VALERIA LIFKE;BERND MUELLER-BECKMANN;TOBIAS SCHNITZER.;
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申请日2007-05-10
分类号C07K16/00;C12N5/02;C12N5/24;
国家 CL
入库时间 2022-08-21 20:08:33

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