首页> 外国专利> methods for modifying the fate of an adenoma and / or adenocarcinoma cell, to induce the formation of a post-mitotic cell from an adenoma and / or adenocarcinoma cell, and to at least partially shrink an adenoma and / or Intestinal adenocarcinoma present in an animal, use of a notch path inhibitor, and pharmaceutical composition

methods for modifying the fate of an adenoma and / or adenocarcinoma cell, to induce the formation of a post-mitotic cell from an adenoma and / or adenocarcinoma cell, and to at least partially shrink an adenoma and / or Intestinal adenocarcinoma present in an animal, use of a notch path inhibitor, and pharmaceutical composition

机译：改变腺瘤和/或腺癌细胞的命运，诱导腺瘤和/或腺癌细胞形成有丝分裂后细胞，并至少部分缩小动物中存在的腺瘤和/或肠腺癌的方法，陷波路径抑制剂的用途和药物组合物

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摘要

METHODS FOR MODIFYING THE DESTINATION OF AN ADENOMA AND / OR ADENOCARCINOMA CELL FOR INDUCING THE FORMATION OF A POST-MYTHOTICAL CELL FROM AN ADENOMA AND / OR ADENOCARCINOMA AND / OR TO THE MENOUS INTESTINAL ADENOCARCINOMA PRESENT IN AN ANIMAL, USE OF A NOTCH PATH INHIBITOR, AND PHARMACEUTICAL COMPOSITION. The invention relates to the field of biochemistry and medicine. More specifically, the invention relates to methods and pharmaceuticals for treating an intestinal neoplasm. The invention describes the surprising discovery that Notch pathway activation inhibitors (e.g. g-secretase inhibitors) are extremely useful in the treatment of intestinal adenoma and / or adenocarcinoma.

机译：修饰腺瘤和/或腺癌细胞的目的地的方法，以诱导从腺瘤和/或腺癌和/或多发于动物的肠道小肠腺瘤形成的继发性细胞的形成，这是由于不经动物而引起的和药物成分。本发明涉及生物化学和医学领域。更具体地，本发明涉及用于治疗肠肿瘤的方法和药物。本发明描述了令人惊讶的发现，即Notch途径激活抑制剂（例如g-分泌酶抑制剂）在治疗肠腺瘤和/或腺癌中极为有用。

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公开/公告号BRPI0517564A

专利类型
公开/公告日2008-10-14

原文格式PDF
申请/专利权人 HUBRECHT LABORATORIUM;
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申请/专利号BR2005PI17564
发明设计人 JOHANNES CAROLUS CLEVERS;MARIA ELISABETH VAN GIJN;JOHANNES HENDRIKUS VAN ES;
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申请日2005-11-10
分类号A61K38/17;A61K38/55;A61P35;
国家 BR
入库时间 2022-08-21 20:08:43

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