compound or a pharmaceutically acceptable salt, solvate or hydrate thereof, pharmaceutical composition, and methods for inhibiting angiogenesis, for inhibiting or reducing tubulin polymerization or tubulin stability in a cell, for inhibiting pde4 activity in a cell , to inhibit tumor necrosis factor-alpha (tnf-alpha) activity in a cell, to treat or ameliorate an inflammatory disorder, to treat or ameliorate cancer, to inhibit cancer cell proliferation, to mark, block or destroy Tumor vasculature function, to tag, block or destroy tumor vessel endothelium, to tag, block or destroy tumor vasculature function and inhibit angiogenesis in a tumor, and to treat or ameliorate a central nervous system disorder