首页> 外国专利> pharmaceutical composition, methods for preventing or treating a liver disease or medical condition in an individual, inhibiting the proliferation of hepatic stellate cells, selectively killing hepatic stellate cells, inhibiting the expression of hepatitis b virus surface antigen in a mammal, and to prevent or treat fibrosis or inflammation in a mammal, and, use of graptopetalum or echeveria

pharmaceutical composition, methods for preventing or treating a liver disease or medical condition in an individual, inhibiting the proliferation of hepatic stellate cells, selectively killing hepatic stellate cells, inhibiting the expression of hepatitis b virus surface antigen in a mammal, and to prevent or treat fibrosis or inflammation in a mammal, and, use of graptopetalum or echeveria

机译：药物组合物，用于预防或治疗个体的肝病或医学状况，抑制肝星状细胞的增殖，选择性杀死肝星状细胞，抑制哺乳动物中乙型肝炎病毒表面抗原的表达以及预防或治疗的方法哺乳动物的纤维化或发炎，以及使用格拉多仑或echeveria

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摘要

PHARMACEUTICAL COMPOSITION, METHODS TO AVOID OR TREAT A HEALTH DISEASE OR MEDICAL CONDITION IN AN INDIVIDUAL, TO INHIBIT THE HEPATIC STAR CELLS, TO SELECTIVELY KILL THE EXHIBA BIOPHIES IN THE HEPATIAN EXHIBIUS MAMMUS, AND TO AVOID OR TREAT FIBROSIS OR INFLAMMATION IN A MAMMER, AND USE OF GRAPTOPETALUM OR ECHEVERIA The present invention relates to compositions comprising Graptopetalum and its uses. Graptopetalum can protect animals from liver disease and medical conditions such as inflammation, steatosis and fibrosis. In particular, Graptopetalum inhibits the proliferation of activated hepatic stellate cells, which play a key role in ligand fibrosis. Graptopetalum also has anti-fibrosis activities as well as inhibits the proliferation of lung fibroblasts. Therefore, in addition to being a prophylactic and therapeutic agent for the lysate, Graptopetalum is useful against fibrosis or inflammation of unbound tissues or organs, in particular lungs, kidneys and bladder. Other plants in the Crassulaceae family, particularly Echeveria, have similar effects to Graptopetalum.

机译：药物成分，在个人中避免或治疗健康疾病或疾病的方法，抑制肝星细胞，有选择地杀死希伯来语埃及象MA的活生生生物，避免或治疗纤维化或瘤变或炎症的方法葡萄属或大肠杆菌的用途本发明涉及包含葡萄属的组合物及其用途。 Graptopetalum可以保护动物免受肝脏疾病和疾病的侵害，例如炎症，脂肪变性和纤维化。尤其是，Graptopetalum抑制活化的肝星状细胞的增殖，而肝星状细胞在配体纤维化中起关键作用。 Graptopetalum还具有抗纤维化活性，并抑制肺成纤维细胞的增殖。因此，除了作为裂解物的预防和治疗剂外，Graptopetalum还可以用于抵抗未结合的组织或器官，特别是肺，肾和膀胱的纤维化或炎症。景天科的其他植物，特别是Echeveria，与Graptopetalum具有相似的作用。

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公开/公告号BRPI0514768A

专利类型
公开/公告日2008-06-24

原文格式PDF
申请/专利权人 RU-CHEIN YU;VETERANS GENERAL HOSPITAL;
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申请/专利号BR2005PI14768
发明设计人 SHIH-LAN HSU;
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申请日2005-08-29
分类号A61K36/752;A61K36/185;
国家 BR
入库时间 2022-08-21 20:08:44

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