首页> 外国专利> compound, pharmaceutical composition, use of a compound, methods for the treatment of gastroesophageal reflux disease, a functional gastrointestinal disorder, and irritable bowel syndrome, for the prevention of reflux, and for the inhibition of transient lower esophageal sphincter relaxations, and, process for the preparation of a compound

compound, pharmaceutical composition, use of a compound, methods for the treatment of gastroesophageal reflux disease, a functional gastrointestinal disorder, and irritable bowel syndrome, for the prevention of reflux, and for the inhibition of transient lower esophageal sphincter relaxations, and, process for the preparation of a compound

机译：化合物，药物组合物，该化合物的用途，用于治疗胃食管反流疾病，功能性胃肠道疾病和肠易激综合症的方法，用于预防反流和抑制短暂性食管下括约肌松弛的方法以及其制备方法化合物的制备

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摘要

COMPOSITION, PHARMACEUTICAL COMPOSITION, USE OF A COMPOUND, METHODS FOR TREATMENT OF GASTROESOPHAGIC REFLUX DISEASE, AND A FUNCTIONAL GASTROINTESTINAL DISORDER, AND FOR IRRITABLE INTENSION, FOR INFLAMMATION OF THE INFRESHENSION AND, PROCESS FOR PREPARING A COMPOUND Text in table No. IV of the summary (Continued from item 5 of the first sheet). The present invention relates to novel compounds having a positive allosteric GABAB receptor modulating effect, methods for preparing said compounds and their use, optionally in combination with a GABAB agonist, for inhibiting lower esophageal sphincter relaxations. for the treatment of gastroesophageal reflux disease, as well as for the treatment of functional gastrointestinal disorders and irritable bowel syndrome (IBS). A compound of the general formula I:

机译：成分，药物成分，化合物的使用，胃食道反流病的治疗方法，功能性胃肠道疾病，肠胃功能紊乱以及肠胃蠕动的意图，以及在表中未编写复合文本的过程。（续第一页的第5项）。本发明涉及具有积极的变构GABA B受体调节作用的新型化合物，制备所述化合物的方法及其任选与GABA B激动剂组合用于抑制食管下括约肌松弛的用途。用于治疗胃食管反流疾病，以及用于治疗功能性胃肠道疾病和肠易激综合症（IBS）。通式Ⅰ的化合物：

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公开/公告号BRPI0512517A

专利类型
公开/公告日2008-03-11

原文格式PDF
申请/专利权人 ASTRAZENECA AB;
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申请/专利号BR2005PI12517
发明设计人 UDO BAUER;WAYNE BRAILSFORD;VIJAY CHHAJLANI;BRYAN EGNER;OLA FJELLSTR÷M;LINDA GUSTAFSSON;JAN MATTSSON;KAROLINA NILSSON;THOMAS OLSSON;
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申请日2005-06-20
分类号C07D471/04;A61K31/435;C07D;C07D233/90;C07D401/12;C07D405/04;C07D409/06;C07D409/12;C07D413/12;
国家 BR
入库时间 2022-08-21 20:08:48

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