首页> 外国专利> conjugated drug and antibody compound, pharmaceutical composition, cell proliferation inhibition methods, cancer treatment, tumor cell growth inhibition and dysfunction-sensitive human patient treatment, cancer cell detection test, industrialized article and method drug and antibody conjugate manufacturing

conjugated drug and antibody compound, pharmaceutical composition, cell proliferation inhibition methods, cancer treatment, tumor cell growth inhibition and dysfunction-sensitive human patient treatment, cancer cell detection test, industrialized article and method drug and antibody conjugate manufacturing

机译：共轭药物和抗体的化合物，药物组合物，细胞增殖抑制方法，癌症治疗，对肿瘤细胞生长的抑制和对功能障碍敏感的人类患者的治疗，癌细胞检测试验，工业化制品和方法药物和抗体缀合物的制造

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DRUG AND ANTIBODY CONJUGATE COMPOUND, PHARMACEUTICAL COMPOSITION, CELL PROLIFERATION INHIBITION, CANCER TREATMENT INHIBITION, TUMOR CELL DISEASE, TUMOR CUSTOM TREATMENT AND METHODS The present invention relates to conjugated drug and antibody compounds of Formula 1, wherein one or more maytansinoid drug moieties (D) are covalently linked by L to an antibody (Ab) which attaches to the ErbB receptor, or attaches to one or more tumor associated antigens or cell surface receptors. These compounds may be used in methods of diagnosing or treating cancer and other diseases and disorders.

机译：药物和抗体缀合物，药物组合物，细胞增殖抑制，癌症治疗抑制，肿瘤细胞疾病，肿瘤定制治疗和方法技术领域本发明涉及式1的缀合药物和抗体化合物，其中一种或多种美登木素生物碱（化合物）通过L与结合至ErbB受体的抗体（Ab）或结合至一种或多种肿瘤相关抗原或细胞表面受体的抗体（Ab）共价连接。这些化合物可用于诊断或治疗癌症以及其他疾病和病症的方法。

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公开/公告号BRPI0510883A

专利类型
公开/公告日2007-12-26

原文格式PDF
申请/专利权人 GENENTECH INC;
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申请/专利号BR2005PI10883
发明设计人 ALLEN J. EBENS JR;FREDERIC S. JACOBSON;PAUL POLAKIS;RALPH H. SCHWALL;MARK X. SLIWKOWSKI;SUSAN D. SPENCER;
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申请日2005-05-31
分类号A61K47/48;A61K39/395;A61P35;C07D491/14;C07D498/18;C07K16/10;C07K16/28;C07K16/30;C07K16/32;C07K16/46;G01N33/574;G01N33/74;
国家 BR
入库时间 2022-08-21 20:08:50

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