首页> 外国专利> Supramolecular complexes of high stoichiometry in systems nanoagregados constituu00ecdos by chlorhexidine or tetracycline incluu00ecdos in cyclodextrin

Supramolecular complexes of high stoichiometry in systems nanoagregados constituu00ecdos by chlorhexidine or tetracycline incluu00ecdos in cyclodextrin

机译:环糊精中洗必泰或四环素的高化学计量比超分子配合物

摘要

Supramolecular complexes of high stoichiometry in systems nanoagregados constituu00ecdos by chlorhexidine or tetracycline incluu00ecdos in cyclodextrin inclusion complexes formed by preparation of antimicrobial and cyclodextrins (CD) mucoadesivos polymers, such as, for example, clorexid INA and cyclodextrin CiX / 225 - CD and tetracycline (TC) and cyclodextrin TC / 225 - CD, in the ratio 1: 1.Have been reported in the patent application. The complex CiX / 225 - CD (1: 1) presented activity than chlorhexidine (C x) pure when tested against bacteria Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis, Enterococcus faecalis.It was also reported higher antimicrobial activity of tetracycline complexed (TC / 225 - CD 1: 1) compared with tetracycline pure cultures of Actinobacillus actinomycetemcomitans.
机译:通过化学洗必太或四环素内含物在环糊精包合物中形成的化学计量比高的超分子超分子络合物,通过制备抗微生物剂和环糊精(CD)粘多糖聚合物形成,例如clorexid INA和//环糊精-CD和四环素(TC)和环糊精TC // <225 -CD,比例为1:1。在专利申请中已有报道。当针对细菌放线杆菌,牙龈卟啉单胞菌,粪肠球菌进行测试时,复杂的CiX / <225-CD(1:1)具有比纯净的洗必泰(C x)更高的活性,并且还报道了四环素复合物(TC)具有更高的抗菌活性。 / <225-CD 1:1)与放线放线放线杆菌的四环素纯培养物相比。

著录项

  • 公开/公告号BR0206336C1

    专利类型

  • 公开/公告日2008-06-24

    原文格式PDF

  • 申请/专利权人 UNIVERSIDADE FEDERAL DE MINAS GERAIS;

    申请/专利号BR20020206336

  • 发明设计人 MARIA ESPERANZA CORTES SEGURA;

    申请日2002-12-06

  • 分类号A61K47/40;A61P23/00;A61P31/00;

  • 国家 BR

  • 入库时间 2022-08-21 20:08:52

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