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Bicyclic Heterocycles 4 - amino substituted quinazoline Derivatives, medicaments containing these Compounds, their use in the treatment of diseases mediated by the activity of the tirosinquinasas and tiroquinasas and processes for their Preparation
Bicyclic Heterocycles 4 - amino substituted quinazoline Derivatives, medicaments containing these Compounds, their use in the treatment of diseases mediated by the activity of the tirosinquinasas and tiroquinasas and processes for their Preparation
Bicyclic Heterocyclic compounds of the General formula (1), tautomeros, their stereoisomers, their mixtures and their salts, especially their physiologically tolerable salts with inorganic or organic acids, which have an inhibitory effect on the signal transduction mediated by tiroquinas As to its use for the treatment of diseases, especially tumor diseases.As well as benign Prostate hyperplasia (BPH), pulmonary and respiratory diseases, and preparation.Claim 1: bicyclic Heterocycles of General formula (1) in which a mean ra RB H Atom; a radical 3-chloro-4 - phenyl Fluorine or a 3 - etinilfenilo RC Group, a radical selected from the group consisting of 1 - Methoxycarbonyl - piperidin-4-yl ILO, 1 - etiloxicarbonil - piperidin ILO - 4 - 1 - Trifluoroacetilpiperidin - 4 - cis-4 - (ILO, metoxicarbonilamino) - ciclohex - 1 - iloTrans-4 - (metoxicarbonilamino ciclohex - 1 - yl) - cis-4 - (etiloxicarbonilamino, ciclohex - yl) - trans - 1, 4 - (etiloxicarbonilamino ciclohex - 1 - yl) - cis-4 - (trifluoracetilamino, ciclohex - 1 - yl) -, trans - 4 - (trifluoracetilamino) - ciclohex - ILO - cis - 1, 4 - (Methoxycarbonyl - N - N - methyl - amino - 1 - yl) - ciclohex, trans-4 - (N - I Xicarbonil - N - methyl - amino - 1 - yl) - ciclohex, cis-4 - (N - etiloxicarbonil - N - methyl - amino) - ciclohex - 1 - iloTrans-4 - (N - etiloxicarbonil - N - methyl - amino - 1 - yl) - ciclohex, cis-4 - (N - trifluoracetil - N - methyl - amino - 1 - yl) - ciclohex, trans-4 - (N - trifluoracetil - N - methyl - amino) - ciclohex - 1 - ILO, cis-4 - phthalimido - Ciclohex - 1 - ILO and trans - 4 - phthalimido - ciclohex - 1 - ilo; RD a H Atom, a methoxy group or 2 - metoxietiloxi ethyloxy,, Eventually in the form of tautomeros, racematos, its enantiomers.Diastereoisomers and their mixtures, and eventually by adding acid salts, solvates and hydrates pharmacologically safe.
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