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Cytoplasmic expression of antibodies, antibody fragments and antibody fragment fusion proteins in E. coli

机译:抗体,抗体片段和抗体片段融合蛋白在细胞中的细胞质表达。大肠杆菌

摘要

The invention relates to the cytoplasmic expression of antibodies, antibody fragments and antibody fragment fusion molecules in E. coli. In particular, antibody fragment fusion molecules having an antibody moiety which is directed against tumors and an enzyme moiety which cleaves a nontoxic prodrug to give the toxic drug can be advantageously prepared in this way while retaining their respective functional properties.
机译:本发明涉及在E中抗体,抗体片段和抗体片段融合分子的细胞质表达。大肠杆菌。特别地,可以以这种方式有利地制备具有片段的融合抗体,其具有针对肿瘤的抗体部分和裂解无毒前药以产生有毒药物的酶部分,同时保留它们各自的功能特性。

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