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Methods of identifying compounds that affect a fatty acid cell-surface receptor

机译:鉴定影响脂肪酸细胞表面受体的化合物的方法

摘要

The present invention provides methods for screening and identifying compounds that affect the metabolism of fatty acids and fatty acid derivatives, and thus for compounds that possess anti-diabetic as well as anti-obesity properties and possess the ability to affect the levels of chylomicrons, triacylglycerols, cholesterols, and fatty acids in a patient. Kits and compositions for screening and identifying such compounds are also provided. The invention is predicated on the identification of a physiological receptor for free fatty acids and anti-diabetic and anti-obesity drugs.
机译:本发明提供了筛选和鉴定影响脂肪酸和脂肪酸衍生物代谢的化合物的方法,从而提供了具有抗糖尿病和抗肥胖症特性并且能够影响乳糜微粒,三酰基甘油水平的化合物的筛选和鉴定方法。 ,胆固醇和脂肪酸。还提供了用于筛选和鉴定此类化合物的试剂盒和组合物。本发明基于对游离脂肪酸以及抗糖尿病和抗肥胖药的生理受体的鉴定。

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