首页> 外国专利> Thyroid sodium/iodide symporter and nucleic acid encoding same

Thyroid sodium/iodide symporter and nucleic acid encoding same

机译:甲状腺钠/碘转运体及其编码核酸

摘要

The present invention provides a purified and isolated nucleic acid encoding a sodium/iodide symporter. The present invention also provides purified sodium/iodide symporter, a vector comprising nucleic acid encoding sodium/iodide symporter, a host cell transformed with the vector, and a method for producing recombinant sodium/iodide symporter. In addition, the present invention provides nucleic acid probes and mixtures thereof specific for sodium/iodide symporter nucleic acid and antibodies immunoreactive with sodium/iodide symporter. The present invention also provides a method for diagnosing and treating thyroid disorders associated with non-functional sodium/iodide symporter. Furthermore, the present invention provides a method for the selective ablation of tissue. The present invention also provides a method for identifying an iodide transport protein in non-thyroid tissue. Finally, the present invention provides a non-human, transgenic model for a thyroid disorder.
机译:本发明提供了编码钠/碘同向转运蛋白的纯化和分离的核酸。本发明还提供了纯化的钠/碘同向转运体,包含编码钠/碘同向转运体的核酸的载体,用该载体转化的宿主细胞以及生产重组钠/碘同向转运体的方法。另外,本发明提供了对钠/碘转运体核酸特异性的核酸探针及其混合物,以及与钠/碘转运体免疫反应的抗体。本发明还提供了用于诊断和治疗与无功能钠/碘转运体有关的甲状腺疾病的方法。此外,本发明提供了一种用于组织的选择性消融的方法。本发明还提供了一种在非甲状腺组织中鉴定碘化物转运蛋白的方法。最后,本发明提供了甲状腺疾病的非人类转基因模型。

著录项

  • 公开/公告号US7320863B2

    专利类型

  • 公开/公告日2008-01-22

    原文格式PDF

  • 申请/专利权人 NANCY CARRASCO;GE DAI;ORLIE LEVY;

    申请/专利号US20040937239

  • 发明设计人 NANCY CARRASCO;GE DAI;ORLIE LEVY;

    申请日2004-09-09

  • 分类号C12Q1/68;C07H21/02;C07H21/04;

  • 国家 US

  • 入库时间 2022-08-21 20:10:00

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