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Diagnostic procedures using ¹²⁹Xe spectroscopy characterstic chemical shift to detect pathology in vivo

机译：使用^{129 Xe光谱学进行特征性化学位移的诊断程序以检测体内病理}

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An in vivo non-invasive method for detecting and/or diagnosing a pathological condition using hyperpolarized ¹²⁹Xe spectroscopy is disclosed. Generally stated, the method includes determining the magnitude of spectral peaks which represent particular chemical shifts and comparing the observed magnitudes to those of healthy individuals. Preferably, the method includes subtracting substantial backgrounds and accounting for secondary conditions such as the polarization of hyperpolarized gas administered. Additionally, a quantitative analysis of hyperpolarized ¹²⁹Xe spectra advantageously allows, a physician to establish the extent of disease progression. Advantageously, this method can be used regardless of the method of hyperpolarized ¹²⁹Xe administration.

机译：公开了一种使用超极化^{129 Xe光谱法检测和/或诊断病理状况的体内无创方法。一般而言，该方法包括确定代表特定化学位移的光谱峰的幅度，并将观察到的幅度与健康个体的幅度进行比较。优选地，该方法包括减去实质背景并考虑次要条件，例如所给予的超极化气体的极化。另外，对超极化的^{129 Xe光谱的定量分析有利地允许医师确定疾病进展的程度。有利地，可以使用该方法而与超极化的^{129 Xe施用方法无关。}}}

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公开/公告号US7357917B2

专利类型
公开/公告日2008-04-15

原文格式PDF
申请/专利权人 BASTIAAN DRIEHUYS;
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申请/专利号US20040761794
发明设计人 BASTIAAN DRIEHUYS;
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申请日2004-01-21
分类号A61B5/055;
国家 US
入库时间 2022-08-21 20:11:27

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Diagnostic procedures using 129Xe spectroscopy characterstic chemical shift to detect pathology in vivo

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Diagnostic procedures using ¹²⁹Xe spectroscopy characterstic chemical shift to detect pathology in vivo