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p53-dependent apoptosis-inducing protein and method of screening for apoptosis regulator
p53-dependent apoptosis-inducing protein and method of screening for apoptosis regulator
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机译:p53依赖性细胞凋亡诱导蛋白及细胞凋亡调控因子的筛选方法
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摘要
p53-dependent Damage-Inducible Nuclear Protein 1 (p53DINP1 protein) is a p53-induced nuclear protein that induces p53-dependent apoptosis by regulating p53 function through Ser 46 phosphorylation. A DNA encoding p53DINP1 can be applied as anticancer agents for destroying neoplasms such as tumors, and as therapeutic or preventive agents for diseases associated with p53-mediated apoptosis abnormalities. It is also possible to apply the above protein and DNA in methods of screening for candidate compounds for regulating p53-mediated apoptosis.
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