首页>
外国专利>
Biomimetic Process For Coating Substrates With A Biomimetic Solution Containing A Bioactive Substance And Use Of Said Process And Substrates In Bone, Connective Tissue-, Fat Tissue-And Muscle Tissue Engineering
Biomimetic Process For Coating Substrates With A Biomimetic Solution Containing A Bioactive Substance And Use Of Said Process And Substrates In Bone, Connective Tissue-, Fat Tissue-And Muscle Tissue Engineering
The invention relates to a biomimetic process for coating a substrate, particularly a medical device, with a biomimetic composition, which comprises:d) producing batchwise in a closed system an acidified biomimetic composition comprising a saline aqueous mixture containing calcium-, magnesium-, phosphate-, bicarbonate ions and a bioactive substance,e) contacting the substrate with said biomimetic composition andf) storing the biomimetic composition in contact with the substrate and allowing a gradual increase of the pH to occur and to cause precipitation of salts and co-precipitation of the bioactive substance on said substrate and to obtain a coated substrate.展开▼
