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Mouse Model of Chronic Heart Failure and Coronary Atherosclerosis Regression

机译：慢性心力衰竭和冠状动脉粥样硬化回归的小鼠模型

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摘要

An animal model has been developed where the animals can survive myocardial infarctions caused by diet-induced coronary atherosclerosis, and live with chronic heart failure. This animal model is a result of reduced activity of scavenger receptor class BI (SR-BI) and ApoE and the inducible activity of the Mx1-Cre gene. In a preferred embodiment, the model is a result of crossbreeding two transgenic mouse lines: a knockout of SR-BI (SRBI^−/−) and an impaired ApoE expressor (Apoe^h/h) to generate a strain referred to as Apoe^h/hSRB1^−/−mice, which is then crossbred to mice that carry the inducible Mx1-Cre transgene. The Apoe^h/hSRB1^−/−mouse model is genetically modified, enabling the offspring to rapidly and permanently lower their high blood cholesterol levels caused by dietary challenge. The ability to rapidly and permanently lower blood cholesterol levels in these mice stops and may cause the regression of occlusive coronary atherosclerosis restoring blood flow to the heart, allowing the mice to survive from myocardial infarction and live with chronic heart failure.

机译：已开发出一种动物模型，其中的动物可以在饮食引起的冠状动脉粥样硬化引起的心肌梗塞中存活，并患有慢性心力衰竭。该动物模型是清道夫受体BI类（SR-BI）和ApoE活性降低以及Mx1-Cre基因的诱导活性降低的结果。在一个优选的实施方案中，该模型是两种转基因小鼠品系杂交的结果：敲除SR-BI（SRBI ^{-/-）和受损的ApoE表达子（Apoe ^{h / h < / Sup>）产生称为Apoe ^{h / h SRB1 ^{-/-小鼠的毒株，然后将其杂交到携带可诱导的Mx1-Cre转基因的小鼠中。 Apoe ^{h / h SRB1 ^{-/-小鼠模型是经过基因改造的，使后代能够快速，持久地降低饮食挑战引起的高胆固醇水平。快速和永久降低这些小鼠的胆固醇水平的能力会停止，并可能导致闭塞性冠状动脉粥样硬化的消退，从而恢复流向心脏的血流，从而使小鼠能够从心肌梗塞中幸存下来并患有慢性心力衰竭。}}}}}}

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公开/公告号US2008075663A1

专利类型
公开/公告日2008-03-27

原文格式PDF
申请/专利权人 ROBERT L. RAFFAI;KARL WEISGRABER;
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申请/专利号US20070765408
发明设计人 KARL WEISGRABER;ROBERT L. RAFFAI;
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申请日2007-06-19
分类号A01K67/00;A61K49/00;
国家 US
入库时间 2022-08-21 20:14:10

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