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monoclonal antibodies that specifically recognize p53 post-translational modification sites, and modification site assay kit containing the antibodies
monoclonal antibodies that specifically recognize p53 post-translational modification sites, and modification site assay kit containing the antibodies
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机译:特异性识别p53翻译后修饰位点的单克隆抗体和包含该抗体的修饰位点检测试剂盒
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摘要
I provides an antibody microarray, etc. which is fixed on the substrate a monoclonal antibody, the antibody-modified site-specific post-translational modifications of p53. A peptide consisting of the amino acid contiguous sequence of at least six amino acid residues given in the amino acid sequence represented by SEQ ID NO: 1, and 1 in the peptide or peptide wherein the amino acid residue is acetylated or phosphorylated to react specifically with the peptide has been added amino acids of any of several monoclonal antibodies which do not react to the peptide which is not acetylated or phosphorylated.
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机译:本发明提供了一种抗体微阵列等,其在基底上固定有单克隆抗体,即p53的抗体修饰的位点特异性翻译后修饰。一种由至少六个氨基酸残基的氨基酸连续序列组成的肽,该氨基酸残基由SEQ ID NO:1表示的氨基酸序列中的至少一个组成,并且该肽或肽中的氨基酸残基被乙酰化或磷酸化以与之特异性反应肽中已添加了几种单克隆抗体的任何氨基酸,这些单克隆抗体不会与未乙酰化或磷酸化的肽发生反应。
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