首页> 外国专利> ARTOCARPIN DERIVATIVE AND ARTOCARPIN ANALOGUE, HAIR-GROWING COMPOSITION AND BRIGHTENING COSMETIC COMPOSITION EACH CONTAINING THE SAME, AND PHARMACEUTICAL AS ANTICANCER AGENT, ANTI-INFLAMMATORY/ANALGESIC AGENT, ANTIPYRETIC AGENT OR ANTIALLERGIC AGENT, AND PHARMACUETICAL FOR TREATING PIGMENTARY DERMATOSIS, EACH CONTAINING THE SAME

ARTOCARPIN DERIVATIVE AND ARTOCARPIN ANALOGUE, HAIR-GROWING COMPOSITION AND BRIGHTENING COSMETIC COMPOSITION EACH CONTAINING THE SAME, AND PHARMACEUTICAL AS ANTICANCER AGENT, ANTI-INFLAMMATORY/ANALGESIC AGENT, ANTIPYRETIC AGENT OR ANTIALLERGIC AGENT, AND PHARMACUETICAL FOR TREATING PIGMENTARY DERMATOSIS, EACH CONTAINING THE SAME

机译：青蒿素衍生物和青蒿素类似物，包括相同成分的长发成分和增白化妆品成分，以及作为抗癌药的抗癌药，抗炎/止痛药，抗老药或抗癌药，

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摘要

PPROBLEM TO BE SOLVED: To provide substances each having the ability to inhibit testosterone-5-reductase activity, the activities of inhibiting and suppressing cancer cell proliferation, the abilities to inhibit cyclooxygenase and 5-lipoxygenase, the ability to inhibit normal melanocyte proliferation, and the ability to inhibit normal fibroblast proliferation. PSOLUTION: The substances are compounds each formed by altering part of an artocarpin molecule and artocarpin analogues including artocarpin's hydrogenated products, demethylated products, methoxy adducts, methylated products, acetylated products, dihydroxylated products, dimethyl ether adducts, epoxidized products, and hydroxylated products. These compounds have the high ability to inhibit testosterone-5-reductase activity, the high activities of inhibiting and suppressing cancer cell proliferation, the high abilities to inhibit cyclooxygenase and 5-lipoxygenase, the high ability to inhibit normal melanocyte proliferation, and the high ability to inhibit normal fibroblast proliferation. PCOPYRIGHT: (C)2008,JPO&INPIT

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要解决的问题：提供具有抑制睾丸激素5-还原酶活性的能力，抑制和抑制癌细胞增殖的活性，抑制环氧合酶和5-脂氧合酶的能力，抑制正常黑素细胞的能力的物质以及抑制正常成纤维细胞增殖的能力。

解决方案：这些物质是分别通过改变木瓜蛋白酶分子和木瓜类似物（包括木瓜氢化产物，脱甲基产物，甲氧基加合物，甲基化产物，乙酰化产物，二羟基化产物，二甲醚加合物，环氧化产物和羟基化产物）形成的化合物。产品。这些化合物具有高的抑制睾丸激素5-还原酶活性的能力，高的抑制和抑制癌细胞增殖的活性，高的抑制环氧合酶和5-脂氧合酶的能力，高的抑制正常黑素细胞增殖的能力以及高的抑制能力。抑制正常的成纤维细胞增殖。

版权：（C）2008，日本特许厅＆INPIT 展开▼

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公开/公告号JP2008044897A

专利类型
公开/公告日2008-02-28

原文格式PDF
申请/专利权人 KANSAI KOSO CO LTD;
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申请/专利号JP20060222752
发明设计人 NAGAHATA TETSUJI;
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申请日2006-08-17
分类号C07D311/30;A61K31/353;C07H15/203;A61K31/7032;C07H17/07;A61P43;A61P35;A61P29;A61P37/08;A61P17;A61K8/49;A61Q7;A61Q19/02;A61K36/60;C07D407/04;C07D407/06;
国家 JP
入库时间 2022-08-21 20:21:42

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