首页> 外国专利> New C-glucoside compounds useful to fight against weakening of natural defense of skin due to e.g. chronological aging, strengthen and stimulate skin immune defense and/or to prevent and/or treat cutaneous autoimmune disease

New C-glucoside compounds useful to fight against weakening of natural defense of skin due to e.g. chronological aging, strengthen and stimulate skin immune defense and/or to prevent and/or treat cutaneous autoimmune disease

机译：新的C-葡糖苷化合物可用于对抗由于例如皮肤引起的皮肤自然防御能力的减弱。按时间顺序老化，加强和刺激皮肤免疫防御和/或预防和/或治疗皮肤自身免疫性疾病

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C-Glycoside compounds (I) and their isomers or solvates, are new. C-Glycoside compounds of formula (I) and their isomers or solvates, are new. S1 : mono- or polysaccharide having free hydroxyl group and 20 sugar units in pyranose and/or furanose forms of L and/D series, e.g. D-glucose, D-galactose, D-mannose, D-xylose, D-lyxose, L-fucose, L-arabinose, L-rhamnose, D-glucuronic acid, D-galacturonic acid, D-iduronic acid, N-acetyl-D-glucosamine, N-acetyl-D-galactosamine, D-maltose, D-lactose, D-cellobiose, D-maltotriose, D-iduronic acid, D-glucuronic acid withe hexosamine e.g. D-galactosamine, D-glucosamine, N-acetyl-D-galactosamine, N-acetyl-D-glucosamine, xylobiose, methyl-beta -xylobioside, xylotriose, xylotetraose, xylopentaose or xylohexaose; R2 : H or CH3; and X : O or OH. An independent claim is included for a composition comprising (I) and an ingredient e.g. scaling-, hydrating-, depigmenting-, propigmenting-, anti-glycation-, dermo-relaxing-, tightening-, anti-pollution- and/or anti-radical-, microcirculating-, energy cell metabolizing-, anti-seborrheic agent, agents for stimulating regrowth, nitric-oxide synthase inhibitors, agents for stimulating (epi)dermic macromolecule synthesis and/or preventing its degradation, agents for stimulating proliferation of fibroblast and/or keratinocytes or stimulating keratinocyte differenciation, myorelaxants and/or and/or promoting the hair fall reduction, antibacterial agents, antagonist, calcium, hormone e.g. estriol or its analogue or thyroxine or its salt, anti-androgen agent, (non)steroid 5-alpha -reductase inhibitor, ATP dependant potassium channel agonist or a plant extract for pro-pigmentation activity. [Image] ACTIVITY : Dermatological; Antipsoriatic; Antiinflammatory; Immunosuppressive; Endocrine-Gen.; Immunomodulator. MECHANISM OF ACTION : None given.

机译：C-糖苷化合物（I）及其异构体或溶剂化物是新的。式（I）的C-糖苷化合物及其异构体或溶剂化物是新的。 S1：L和/ D系列的吡喃糖和/或呋喃糖形式的具有游离羟基和20个糖单元的单糖或多糖，例如L和/ D系列。 D-葡萄糖，D-半乳糖，D-甘露糖，D-木糖，D-lyxose，L-岩藻糖，L-阿拉伯糖，L-鼠李糖，D-葡萄糖醛酸，D-半乳糖醛酸，D-艾杜糖醛酸，N-乙酰基-D-葡萄糖胺，N-乙酰基-D-半乳糖胺，D-麦芽糖，D-乳糖，D-纤维二糖，D-麦芽三糖，D-艾杜糖醛酸，D-葡萄糖醛酸和己糖胺D-半乳糖胺，D-葡萄糖胺，N-乙酰基-D-半乳糖胺，N-乙酰基-D-葡萄糖胺，木糖，甲基-β-木糖苷，木三糖，木四糖，木戊糖或木六糖; R2：H或CH3; X：O或OH。对于包含（I）和成分（例如）的组合物包括独立的权利要求。除垢，补水，脱色，敷料，抗糖化，皮肤松弛，紧绷，抗污染和/或抗自由基，微循环，能量细胞代谢，抗脂溢性药物，刺激再生的药物，一氧化氮合酶抑制剂，刺激（表皮）皮肤大分子合成和/或防止其降解的药物，刺激成纤维细胞和/或角质形成细胞增殖或刺激角质形成细胞分化的药物，髓鞘松弛剂和/或/和/或促进作用减少脱发，抗菌剂，拮抗剂，钙，激素，例如雌三醇或其类似物或甲状腺素或其盐，抗雄激素剂，（非）类固醇5-α-还原酶抑制剂，ATP依赖性钾通道激动剂或植物色素提取物，具有促进色素沉着的作用。 [图像]活动：皮肤病;对牛皮癣;消炎（药;免疫抑制内分泌根免疫调节剂。作用机理：未给出。

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公开/公告号FR2899464A1

专利类型
公开/公告日2007-10-12

原文格式PDF
申请/专利权人 LOREAL SOCIETE ANONYME;
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申请/专利号FR20060051255
发明设计人 CAVEZZA ALEXANDRE;
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申请日2006-04-07
分类号A61K8/49;A61K31/513;A61P17;A61Q19;
国家 FR
入库时间 2022-08-21 20:26:49

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