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synergism of photodynamic and elektropermeationseffekten on cell vitality as a new cytotoxisches resources

机译:光动力和电子渗透作用的协同作用对细胞活力的影响作为一种新的细胞毒素资源

摘要

The present invention is based on the discovery that electroporation of a photosensitive agent in a cell and subsequent activation of the agent provides more effective killing of the electroporated cell than cells exposed to a photosensitive agent alone. The invention provides a method and apparatus for inhibiting cell growth or enhancing cell death. The method includes providing a photosensitive agent to a cell; applying an electric pulse to the cell of a sufficient strength and duration to electroporate the cell with the photosensitive agent; and applying light of an activatable wavelength to the cell thereby activating the agent and inhibiting cell growth or enhancing cell death.
机译:本发明基于以下发现:与单独暴露于光敏剂的细胞相比,细胞中光敏剂的电穿孔和随后的试剂活化提供了对电穿孔细胞的更有效的杀死。本发明提供了抑制细胞生长或增加细胞死亡的方法和设备。该方法包括向细胞提供光敏剂;向细胞施加足够强度和持续时间的电脉冲,以用光敏剂对细胞进行电穿孔;向细胞施加可激活波长的光,从而激活试剂并抑制细胞生长或增加细胞死亡。

著录项

  • 公开/公告号DE69936866D1

    专利类型

  • 公开/公告日2007-09-27

    原文格式PDF

  • 申请/专利权人 GENETRONICS INC.;

    申请/专利号DE1999636866T

  • 发明设计人 BERG HERMANN;LAMBREVA MAYA;

    申请日1999-06-25

  • 分类号A61K41/00;A61N1/32;A61N5/06;

  • 国家 DE

  • 入库时间 2022-08-21 20:27:13

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