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pgc - 1, a novel ppar gamma koaktivator of brown adipose tissue

机译：pgc-1，棕色脂肪组织的新型pparγkoaktivator

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摘要

The invention provides isolated nucleic acids molecules, designated PGC-1 nucleic acid molecules, which encode proteins which can modulate various adipocyte-associated activities including, for example, thermogenesis in adipocytes, e.g., brown adipocytes, and adipogenesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PGC-1 gene has been introduced or disrupted. The invention still further provides isolated PGC-1 proteins, fusion proteins, antigenic peptides and anti-PGC-1 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

机译：本发明提供了分离的核酸分子，称为PGC-1核酸分子，其编码可以调节各种脂肪细胞相关活性的蛋白质，包括例如脂肪细胞，例如棕色脂肪细胞中的生热和脂肪形成。本发明还提供了反义核酸分子，含有PGC-1核酸分子的重组表达载体，已将表达载体引入其中的宿主细胞，以及已引入或破坏了PGC-1基因的非人转基因动物。本发明还进一步提供了分离的PGC-1蛋白，融合蛋白，抗原肽和抗PGC-1抗体。还提供了利用本发明的组合物的诊断，筛选和治疗方法。

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公开/公告号DE69836963D1

专利类型
公开/公告日2007-03-15

原文格式PDF
申请/专利权人 DANA-FARBER CANCER INSTITUTE;
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申请/专利号DE1998636963T
发明设计人 SPIEGELMAN M.;PUIGSERVER PERE;WU ZHIDAN;
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申请日1998-05-29
分类号C07K14/47;G01N33/53;A61K31/7088;A61K38;A61K39/395;A61P3;A61P3/04;A61P3/10;C07K14/575;C07K16/12;C07K16/18;C07K19;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/11;C12Q1/68;G01N33/566;
国家 DE
入库时间 2022-08-21 20:27:24

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