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Preparation of 3-amino-3-methyl-1-butanol, useful as intermediate product in pharmaceutical active substance, comprises reacting e.g. 3-methylbut-3-en-1-ol with nitrile compound and reacting the product with potassium hydroxide solution
Preparation of 3-amino-3-methyl-1-butanol, useful as intermediate product in pharmaceutical active substance, comprises reacting e.g. 3-methylbut-3-en-1-ol with nitrile compound and reacting the product with potassium hydroxide solution
Preparation of 3-amino-3-methyl-1-butanol (I) comprises reacting 3-methylbut-3-en-1-ol or 3-methylbut-2-en-1-ol with a nitrile compound (a) in the presence of an acid condensation agent; reacting the obtained product with an aqueous potassium hydroxide solution and extracting the product using a suitable solvent. Preparation of 3-amino-3-methyl-1-butanol (I) comprises reacting 3-methylbut-3-en-1-ol or 3-methylbut-2-en-1-ol with a nitrile compound of formula R1-CN (a) in the presence of an acid condensation agent; reacting the obtained product with an aqueous potassium hydroxide solution and extracting the product using a suitable solvent. R1H, 1-6C alkyl, 2-6C alkenyl or phenyl containing one or more residues, which are inert under reaction conditions, preferably methyl.
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机译：3-氨基-3-甲基-1-丁醇的制备（I）包括使3-甲基丁-3-烯-1-醇或3-甲基丁-2-烯-1-醇与腈化合物（a）在其中反应。存在酸缩合剂;使所得产物与氢氧化钾水溶液反应，并使用适当的溶剂萃取产物。 3-氨基-3-甲基-1-丁醇的制备（I）包括使3-甲基丁-3-烯-1-醇或3-甲基丁-2-烯-1-醇与式R1>-的腈化合物反应CN（a）在酸缩合剂的存在下;使所得产物与氢氧化钾水溶液反应，并使用适当的溶剂萃取产物。 R 1＞ H，含有一个或多个在反应条件下为惰性的残基的1-6个烷基，2-6C个烯基或苯基，优选为甲基。
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