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METHOD FOR PRODUCTION OF ASSOCIATED PERTUSIS, DIPHTHERIA, AND TETANUM VACCINE

机译:产生相关百日咳,二破和破伤风疫苗的方法

摘要

FIELD: microbiology, in particular production of associated pertusis, diphtheria, and tetanum vaccine.;SUBSTANCE: claimed method includes blending of pertusis component, diphtheria and tetanum anatoxins; mixture sorption on aluminum hydroxide; mixture dosage into container, mixture lyophilizing and container sealing. As pertusis component cell-free pertusis anatoxin in concentration of 40-50 mug/ml is used. Mixture of cell-free pertusis anatoxin, diphtheria and tetanum anatoxins is sorbed on aluminum hydroxide. Then polyoxydonium as immunomodulator in amount of 0,5-0,52 mug/g in introduced into abovementioned mixture, mixture is held for 18-20 h at 4-10°C, sucrose is added up to finish concentration and mixture is held for 1 h at 4-10°C.;EFFECT: vaccine of decreased reactogenicity.;2 ex, 1 tbl
机译:技术领域:微生物学,特别是相关百日咳,白喉和破伤风疫苗的生产。所要求保护的方法包括将百日咳成分,白喉和破伤风抗毒素混合。混合物在氢氧化铝上的吸附;将混合物放入容器中,将混合物冻干并密封容器。作为百日咳成分,使用浓度为40-50杯/毫升的无细胞百日咳抗毒素。无细胞百日咳抗毒素,白喉和破伤风抗毒素的混合物被吸附在氢氧化铝上。然后以0.5-0.52 /杯子/ g的量将聚氧don作为免疫调节剂引入上述混合物中,将混合物在4-10℃下保持18-20h,添加蔗糖至终浓度,并将混合物保持在4-10°C下放置1小时;效果:反应原性降低的疫苗。2ex,1 tbl

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