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ANALOGS OF FATTY ACIDS, METHOD FOR THEIR PREPARING, METHOD FOR TREATMENT OF DISEASES, PHARMACEUTICAL COMPOSITION AND NUTRIENT COMPOSITION COMPRISING ANALOGS THEREOF AND METHOD FOR PROVIDING BODY MASS LOSS
ANALOGS OF FATTY ACIDS, METHOD FOR THEIR PREPARING, METHOD FOR TREATMENT OF DISEASES, PHARMACEUTICAL COMPOSITION AND NUTRIENT COMPOSITION COMPRISING ANALOGS THEREOF AND METHOD FOR PROVIDING BODY MASS LOSS
FIELD: organic chemistry, medicine, pharmacy.;SUBSTANCE: invention relates to novel analogs of fatty acids of the general formula (I): R1-[Xi-CH2]n-COOR2 wherein R1 represents (C6-C24)-alkene with one or more double bond, and/or (C6-C24)-alkyne; R2 represents hydrogen atom or (C1-C4)-alkyl; n represents a whole number from 1 to 12; I represents an uneven number and shows position relatively to COOR2; Xi is chosen independently of one another from the group comprising oxygen (O), sulfur (S) and selenium (se) atom and -CH2 under condition that at least one among Xi is not -CH2 and under condition that if R1 represents alkyne then a carbon-carbon triple bond is located between (-1)-carbon atom and (-2)-carbon atom, or between (-2)-carbon atom and (-3)-carbon atom, or between (-3)-carbon atom and (-4)-carbon atom, and to their salts and complexes. The claimed compounds can be used in treatment and/or prophylaxis of X syndrome, obesity, hypertension, hepatic fatty dystrophy, diabetes mellitus, hyperglycemia, hyperinsulinemia and stenosis. Also, invention relates to methods for preparing novel analogs of fatty acids. Also, invention relates to a nutrient composition comprising indicated analogs of fatty acids and to a method for reducing the total body mass or amount of lipid tissue in humans or animals. Invention provides the development of novel fatty acid analogs-base compositions or methods for suppression of stenosis, restenosis or associated disorders as result of proliferation and mobilization of vessel smooth muscle cells after, for example, traumatic damages of vessels during surgery operation in vessels.;EFFECT: improved preparing method, valuable medicinal properties of analogs.;12 cl, 2 dwg, 7 ex
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机译：技术领域：本发明涉及通式（I）的脂肪酸的新类似物：R 1 -[X i -CH 2 ] n -COOR 2 其中R 1 表示（C 6 -C具有一个或多个双键的 24 ）-烯烃和/或（C 6 -C 24 ）-炔烃; R 2 代表氢原子或（C 1 -C 4 ）-烷基; n表示1到12的整数;我代表一个不均匀的数字，并显示相对于COOR 2 的位置; X i 彼此独立地选自氧（O），硫（S）和硒（se）原子以及-CH 2 X i 中的一个不是-CH 2 ，并且在以下条件下：如果R 1 表示炔烃，则碳-碳三键位于（ -1）-碳原子和（-2）-碳原子，或（-2）-碳原子与（-3）-碳原子之间，或（-3）-碳原子与（-4）-碳原子之间，以及它们的盐和配合物。所要求保护的化合物可以用于治疗和/或预防X综合征，肥胖症，高血压，肝脂肪营养不良，糖尿病，高血糖症，高胰岛素血症和狭窄。同样，本发明涉及用于制备脂肪酸的新型类似物的方法。另外，本发明涉及包含所示的脂肪酸类似物的营养组合物，并且涉及减少人或动物的总体重或脂质组织的量的方法。本发明提供了新的基于脂肪酸类似物的组合物或方法的开发，该组合物或方法用于抑制狭窄，再狭窄或相关疾病，所述狭窄是由于血管平滑肌细胞的增生和动员引起的，所述血管平滑肌细胞例如在血管的外科手术过程中受到血管损伤之后。效果：改进的制备方法，类似物的重要药用价值。; 12 cl，2 dwg，7 ex
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