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Anti-cancer Agent Loaded Hydrophobic Bile Acid Conjugated Hydrophilic Chitosan Oligosaccharide Nanoparticles and Preparation Method Thereof

机译:载有抗癌剂的疏水性胆汁酸共轭亲水壳聚糖寡糖纳米颗粒及其制备方法

摘要

Disclosed herein are hydrophobic bile acid- conjugated hydrophilic chitosan oligosaccharide nanoparticles with anticancer agent loaded therein and a method for preparing the same. The hydrophobic bile acid- conjugated hydrophilic chitosan oligosaccharide nanoparticles form self-aggregates in aqueous phases. With a high load of anticancer agents, the hydrophobic bile acid-conjugated chitosan oligosaccharide nanoparticles with anticancer agents loaded therein exhibit excellent cytotoxicity against cancer cells. Also, the nanoparticles release the anticancer agent in a sustained manner therefrom, thereby exhibiting anticancer activity for a prolong period of time. Therefore, the nanoparticles are very useful in cancer chemotherapy.
机译:本文公开了其中装载有抗癌剂的疏水性胆汁酸缀合的亲水性壳聚糖寡糖纳米颗粒及其制备方法。疏水胆汁酸缀合的亲水壳聚糖寡糖纳米颗粒在水相中形成自聚集体。具有高负载的抗癌剂,其中装载有抗癌剂的疏水性胆汁酸缀合的壳聚糖寡糖纳米颗粒表现出对癌细胞的优异的细胞毒性。而且,纳米颗粒以持续的方式从其释放抗癌剂,从而长时间显示出抗癌活性。因此,纳米颗粒在癌症化学疗法中非常有用。

著录项

  • 公开/公告号KR100762954B1

    专利类型

  • 公开/公告日2007-10-04

    原文格式PDF

  • 申请/专利权人

    申请/专利号KR20060008233

  • 申请日2006-01-26

  • 分类号A61K31/722;A61P35;

  • 国家 KR

  • 入库时间 2022-08-21 20:31:19

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