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IMPROVEMENT OF LEVELS AND/OR SUSTAINABILITY OF DNA-BASED GENE EXPRESSION
IMPROVEMENT OF LEVELS AND/OR SUSTAINABILITY OF DNA-BASED GENE EXPRESSION
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机译：DNA基因表达水平的提高和/或可持续性
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摘要
The invention encompasses methods for improving the level and/or suslainability of expression for a target nucleic acid in a eukaryotic cell comprising: (a) modifying the target nucleic acid to introduce or to comprise signals that limit or constrain the positions of nucleosome cores, and (b) introducing the modified target nucleic acid into the eukaryotic cell, wherein the modified target nucleic acid has improved levels and/ or sustainability of expression compared to original unmodified nucleic acid.
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