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METHOD OF TREATING DRY EYE DISEASE WITH NON-DRYING ANTIHISTAMINES

机译:非干燥抗组胺药治疗干眼病的方法

摘要

A method and preparation for reducing dry eye symptoms and promoting tear secretion in a subject in need of such treatment is disclosed. The method comprises administering to the eyes of the subject a non-drying antihistamine compound, such as epinastine hydrochloride, in an amount effective to reduce dry eye symptoms and stimulate tear fluid secretion. Pharmaceutical formulations and methods of making the same are also disclosed. Methods of administering the compound include topical administration via a liquid, gel, cream, or as part of a contact lens or a continuous or selective release device; or systemic administration via nasal drops or spray, inhalation by nebulizer or other device, oral form (liquid or pill), injectable, intra-operative instillation or suppository form.
机译:公开了一种在需要这种治疗的对象中减轻干眼症状并促进泪液分泌的方法和制剂。该方法包括以有效减轻干眼症状和刺激泪液分泌的量向受试者的眼睛施用非干燥的抗组胺化合物,例如盐酸萘哌汀。还公开了药物制剂及其制备方法。施用化合物的方法包括通过液体,凝胶,乳膏或作为隐形眼镜或连续或选择性释放装置的一部分局部施用;或通过局部施用。或通过滴鼻剂或喷雾剂全身给药,通过雾化器或其他装置吸入,口服形式(液体或丸剂),可注射,术中滴注或栓剂形式。

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