首页> 外国专利> HOMOEOLOGOUS REGION JUDGING METHOD BY HOMO JUNCTION FINGERPRINT METHOD, HOMOEOLOGOUS REGION JUDGING DEVICE, AND GENE SCREENING METHOD

HOMOEOLOGOUS REGION JUDGING METHOD BY HOMO JUNCTION FINGERPRINT METHOD, HOMOEOLOGOUS REGION JUDGING DEVICE, AND GENE SCREENING METHOD

机译:均势指印法,均势区判断装置和基因筛选方法的均势区判断方法

摘要

[PROBLEMS] To provide a method for efficiently searching for a recessive disease gene without needing any pedigree analysis. [MEANS FOR SOLVING PROBLEMS] In a homoeologous region judging method, the following steps are conducted. It is judged whether or not the base constituting a polymorphic marker of a sample DNA of diploid or higher polyploidy is a homojunction. Homojunction region information representing the region of the sample DNA where polymorphic markers judged as homojunctions continue is acquired. If the continuous probability and/or continuous distance of the polymorphic markers contained in the homojunction region information satisfy a predetermined judgment condition, the homojunction region is judged as a homoeologous region. A homoeologous region judging device and a gene screening method for identifying a disease susceptibility gene from the judged homoeologous region are also provided.
机译:[问题]提供一种无需任何谱系分析即可有效搜索隐性疾病基因的方法。 [解决问题的手段]在同源区域判断方法中,执行以下步骤。判断构成二倍体或更高级多倍体的样品DNA的多态性标记的碱基是否是同质结。获取表示样品DNA的被识别为同质连接的多态性标记继续存在的区域的同质连接区域信息。如果包含在同质结区域信息中的多态性标记的连续概率和/或连续距离满足预定的判断条件,则将该同质结区域判断为同源区域。还提供了用于从所判断的同源区域中识别疾病易感基因的同源区域判断装置和基因筛选方法。

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