首页> 外国专利> Thrombin derivatives and process for producing the same, anhydrothrombin derivatives and process for producing the same, platelet agglutination-inducing compositions, method of inducing platelet agglutination, clinical test reagents, clinical test method, thrombosis inhibitors, adsorbent and process for producing the same

Thrombin derivatives and process for producing the same, anhydrothrombin derivatives and process for producing the same, platelet agglutination-inducing compositions, method of inducing platelet agglutination, clinical test reagents, clinical test method, thrombosis inhibitors, adsorbent and process for producing the same

机译：凝血酶衍生物及其制备方法，脱水凝血酶衍生物及其制备方法，诱导血小板凝集的组合物，诱导血小板凝集的方法，临床试验试剂，临床试验方法，血栓形成抑制剂，吸附剂及其制备方法

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摘要

A thrombin derivative having a lowered fibrinogen activity, a process for producing thereof, an anhydrothrombin derivative having a lowered fibrinogen activity, and a process for producing thereof are provided. This invention is to provide a thrombin derivative formed by modifying carboxyl group(s) of the thrombin and an anhydrothrombin derivative formed by modifying carboxyl group (s) of the anhydrothrombin. The thrombin derivative can be utilized as a composition for inducing platelet aggregation and further as a reagent of specific aggregation for clinical testing and the like. By the affinity chromatography having carboxyl group(s) bound with anhydrothrombin as a ligand, it is made possible to carry out necessary purification with high selectivity relative to the blood coagulation factor VIII. Further, the anhydrothrombin derivative which results from modifying carboxyl group(s) of anhydrothrombin produces sufficient antithrombogenic effects at a smaller amount as compared with the previous anhydrothrombin and, therefore, can be utilized as an agent for inhibiting the thrombogenesis.

机译：本发明提供了一种纤维蛋白原活性降低的凝血酶衍生物，其制造方法，纤维蛋白原活性降低的脱水凝血酶衍生物及其制造方法。本发明提供通过修饰凝血酶的羧基形成的凝血酶衍生物和通过脱水凝血酶的羧基形成的脱水凝血酶衍生物。凝血酶衍生物可以用作诱导血小板凝集的组合物，还可以用作临床试验等的特异性凝集的试剂。通过具有结合有脱水凝血酶的羧基的配体的亲和色谱，可以相对于凝血因子VIII以高选择性进行必要的纯化。此外，与先前的脱水凝血酶相比，由修饰脱水凝血酶的羧基产生的脱水凝血酶衍生物以较小的量产生足够的抗血栓形成作用，因此，可以用作抑制血栓形成的试剂。

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公开/公告号AU2002238965B8

专利类型
公开/公告日2007-05-17

原文格式PDF
申请/专利权人 FUJIMORI KOGYO CO. LTD.;JNC CORPORATION;
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申请/专利号AU20020238965
发明设计人 KAZUYA HOSOKAWA;
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申请日2002-03-19
分类号C07K14/745;A61K38/48;A61P7/02;A61P43;C12N9/74;G01N33/86;
国家 AU
入库时间 2022-08-21 20:53:16

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