首页> 外国专利> WHITE HAIR DEVELOPMENT MODEL ANIMAL, METHOD FOR ESTABLISHINGWHITE HAIR DEVELOPMENT MODEL ANIMAL, METHOD FOR PASSAGE OF WHITE HAIR DEVELOPMENT MODEL ANIMAL, METHOD FOR STUDY ON WHITE HAIR DEVELOPMENT, SCREENING METHOD FOR WHITE HAIR DEVELOPMENT-CONTROL MEANS, AND COMPOSITION FOR CONTROL OF WHITE HAIR DEVELOPMENT

WHITE HAIR DEVELOPMENT MODEL ANIMAL, METHOD FOR ESTABLISHINGWHITE HAIR DEVELOPMENT MODEL ANIMAL, METHOD FOR PASSAGE OF WHITE HAIR DEVELOPMENT MODEL ANIMAL, METHOD FOR STUDY ON WHITE HAIR DEVELOPMENT, SCREENING METHOD FOR WHITE HAIR DEVELOPMENT-CONTROL MEANS, AND COMPOSITION FOR CONTROL OF WHITE HAIR DEVELOPMENT

机译：白毛发育模型动物，白毛发育模型动物的建立方法，白毛发育模型动物的通行方法，白毛发育研究的方法，白毛发育控制手段的筛选方法以及白毛发育控制的组成

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摘要

A model animal for the development of white hairs, which has such a phenotyp e that black or almost black hairs are grown after birth and white hairs are spontaneously developed with aging. This model animal is a non-human mammal, more preferably a rodential animal, particularly preferably a mouse or rat which has a genotype where an activated RET gene is transformed heterozygous ly and where an endothelin receptor B (Ednrb) gene is heterozygously deficient or alternatively an Ednrb gene is homozygously or heterozygously deficient and the Ednrb gene is homozygously or heterozygously introduced under the contro l of a DbH promoter. Thus, a white hair development model animal can be provid ed which is most suitable for the study on the mechanism of white hair development in human or the research on pharmaceutical preparations or treatments for preventing the development of white hairs.

机译：一种用于白发发育的模型动物，其表型如此，即出生后会长出黑色或几乎黑色的毛发，而白发则随着年龄的增长而自发发育。该模型动物是非人类哺乳动物，更优选为啮齿类动物，特别优选具有基因型的小鼠或大鼠，其中激活的RET基因被杂合地转化，并且内皮素受体B（Ednrb）基因杂合地缺乏或替代。 Ednrb基因是纯合或杂合缺失的，而Ednrb基因是在DbH启动子的控制下纯合或杂合导入的。因此，可以提供最适合人类白发发育机理的研究或防止白发发育的药物制剂或治疗方法的研究的白发发育模型动物。

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公开/公告号CA2611722A1

专利类型
公开/公告日2007-01-11

原文格式PDF
申请/专利权人 CHUBU UNIVERSITY EDUCATIONAL FOUNDATION;
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申请/专利号CA20062611722
发明设计人 KATO MASASHI;
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申请日2006-02-10
分类号C12N15;A01K67/02;A01K67/027;A61K45;A61P17;C12N15/09;G01N33/15;
国家 CA
入库时间 2022-08-21 20:53:47

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